• Gene id: 286097

Gene Summary

• Gene Symbol: MICU3   Gene   UCSC   Ensembl
• Aliases: EFHA2
• Gene name: mitochondrial calcium uptake family member 3
• Alternate names: calcium uptake protein 3, mitochondrial, EF hand domain family A2, EF-hand domain family, member A2, EF-hand domain-containing family member A2, mitochondrial uptake family, member 3,
• Gene location: 8p22 (17027237: 17133068)     Exons: 20     NC_000008.11
• OMIM: 610339

Protein Summary

• Protein general information: Q86XE3  
  • Name: Calcium uptake protein 3, mitochondrial (EF hand domain containing family member A2)
  • Length: 530  
  • Mass: 60711
• Sequence:

  MAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGG
  GLVGLVCYQLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVAIGRTDIEDLDLYATSRERRFR
  LFASIECEGQLFMTPYDFILAVTTDEPKVAKTWKSLSKQELNQMLAETPPVWKGSSKLFRNLKEKGVISYTEYLF
  LLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKREIKGDEEKRAMLRLQLYGYHSPTNSVLKT
  DAEELVSRSYWDTLRRNTSQALFSDLAERADDITSLVTDTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVLEIE
  FLSYSNGMNTISEEDFAHILLRYTNVENTSVFLENVRYSIPEEKGITFDEFRSFFQFLNNLEDFAIALNMYNFAS
  RSIGQDEFKRAVYVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLKK
  ELHSR

• Structural information:
  • Protein Domains: (232..26-)
    (/note="EF-hand-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (401..43-)
    (/note="EF-hand-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (470..50-)
    (/note="EF-hand-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PR-)
  • Interpro: IPR011992  IPR018247  IPR002048  IPR039800  
  • Prosite: PS00018 PS50222
  • PDB: 6AGI 6AGJ
  • PDBsum: 6AGI 6AGJ
  • STRING: ENSP00000321455
• Other Databases: GeneCards:  MICU3  Malacards:  MICU3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005509	calcium ion binding	IEA	molecular function
GO:0006851	mitochondrial calcium ion transmembrane transport	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0006851	mitochondrial calcium ion transmembrane transport	TAS	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881