• Gene id: 285755

Gene Summary

• Gene Symbol: PPIL6   Gene   UCSC   Ensembl
• Aliases: PPIase, RSPH12, bA425D10.6, dJ919F19.1
• Gene name: peptidylprolyl isomerase like 6
• Alternate names: probable inactive peptidyl-prolyl cis-trans isomerase-like 6, cyclophilin-like protein PPIL6, peptidyl-prolyl cis-trans isomerase-like 6, peptidyl-prolyl cis-trans isomerase-like variant a, peptidylprolyl isomerase (cyclophilin)-like 6, problable inactive pept,
• Gene location: 6q21 (109441170: 109390214)     Exons: 13     NC_000006.12

Protein Summary

• Protein general information: Q8IXY8  
  • Name: Probable inactive peptidyl prolyl cis trans isomerase like 6 (PPIase) (Cyclophilin like protein PPIL6) (Rotamase PPIL6)
  • Length: 311  
  • Mass: 35228
• Sequence:

  MARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAAENLKNNHPSKFEDPILVPLQEFAWHQYLQEK
  KRELKNETWEYSSSVISFVNGQFLGDALDLQKWAHEVWDIVDIKPSALYDALTEDFSAKFLRDTKHDFVFLDICI
  DSSPIGRLIFELYCDVCPKTCKNFQVLCTGKAGFSQRGIRLHYKNSIFHRIVQNGWIQGGDIVYGKGDNGESIYG
  PTFEDENFSVPHNKRGVLGMANKGRHSNGSQFYITLQATPYLDRKFVAFGQLIEGTEVLKQLELVPTQNERPIHM
  CRITDSGDPYA

• Structural information:
  • Protein Domains: (145..30-)
    (/note="PPIase-cyclophilin-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00156"-)
  • Interpro: IPR029000  IPR002130  
  • Prosite: PS50072
  • STRING: ENSP00000392257
• Other Databases: GeneCards:  PPIL6  Malacards:  PPIL6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0000413	protein peptidyl-prolyl isomerization	IBA	biological process
GO:0006457	protein folding	IBA	biological process
GO:0016018	cyclosporin A binding	IDA	NOT|molecular function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IDA	NOT|molecular function
GO:0000413	protein peptidyl-prolyl isomerization	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray