• Gene id: 285533

Gene Summary

• Gene Symbol: RNF175   Gene   UCSC   Ensembl
• Gene name: ring finger protein 175
• Alternate names: RING finger protein 175,
• Gene location: 4q31.3 (153760982: 153710159)     Exons: 12     NC_000004.12

Protein Summary

• Protein general information: Q8N4F7  
  • Name: RING finger protein 175
  • Length: 328  
  • Mass: 38266
• Sequence:

  MAAGTAARKAAPVLEAPPQQEQLSHTKLSAEDTWNLQQERMYKMHRGHDSMHVEMILIFLCVLVIAQIVLVQWRQ
  RHGRSYNLVTLLQMWVVPLYFTIKLYWWRFLSMWGMFSVITSYILFRATRKPLSGRTPRLVYKWFLLIYKLSYAF
  GVVGYLAIMFTMCGFNLFFKIKARDSMDFGIVSLFYGLYYGVMGRDFAEICSDYMASTIGFYSVSRLPTRSLSDN
  ICAVCGQKIIVELDEEGLIENTYQLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMISNPWERTHFLYGQI
  LDWLRYLVAWQPVVIGIVQGIIYSLGLE

• Structural information:
  • Interpro: IPR040176  IPR001841  IPR013083  
  • Prosite: PS50089
  • STRING: ENSP00000340979
• Other Databases: GeneCards:  RNF175  Malacards:  RNF175

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030433	ubiquitin-dependent ERAD pathway	IBA	biological process
GO:0000139	Golgi membrane	IBA	cellular component
GO:0005789	endoplasmic reticulum membrane	IBA	cellular component
GO:0030968	endoplasmic reticulum unfolded protein response	IBA	biological process
GO:0061630	ubiquitin protein ligase activity	IBA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq