• Gene id: 285193

Gene Summary

• Gene Symbol: DUSP28   Gene   UCSC   Ensembl
• Aliases: DUSP26, VHP
• Gene name: dual specificity phosphatase 28
• Alternate names: dual specificity phosphatase 28,
• Gene location: 2q37.3 (240559238: 240565255)     Exons: 3     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q4G0W2  
  • Name: Dual specificity phosphatase 28 (EC 3.1.3.16) (EC 3.1.3.48)
  • Length: 176  
  • Mass: 18324
• Sequence:

  MGPAEAGRRGAASPVPPPLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPA
  EDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQL
  QKYEEALQAQSCLQGEPPALGLGPEA

• Structural information:
  • Protein Domains: (76..13-)
    (/note="Tyrosine-protein-phosphatase")
  • Interpro: IPR000340  IPR029021  IPR000387  IPR020422  
  • Prosite: PS50056 PS50054
  • PDB: 5Y15 5Y16
  • PDBsum: 5Y15 5Y16
  • STRING: ENSP00000385885
• Other Databases: GeneCards:  DUSP28  Malacards:  DUSP28

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016311	dephosphorylation	IDA	biological process
GO:0016791	phosphatase activity	IDA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA	molecular function
GO:0016791	phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq