• Gene id: 28512

Gene Summary

• Gene Symbol: NKIRAS1   Gene   UCSC   Ensembl
• Aliases: KBRAS1, kappaB-Ras1
• Gene name: NFKB inhibitor interacting Ras like 1
• Alternate names: NF-kappa-B inhibitor-interacting Ras-like protein 1, I-kappa-B-interacting Ras-like protein 1, NFKB inhibitor interacting Ras-like protein 1, kappa B-Ras protein 1, kappa B-ras 1,
• Gene location: 3p24.2 (23946561: 23889948)     Exons: 13     NC_000003.12
• OMIM: 604496

Protein Summary

• Protein general information: Q9NYS0  
  • Name: NF kappa B inhibitor interacting Ras like protein 1 (I kappa B interacting Ras like protein 1) (Kappa B Ras protein 1) (KappaB Ras1)
  • Length: 192  
  • Mass: 21643
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLYDTRGLQEGVELPKHY
  FSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKIDLSEQRQVDAEVAQQWAKSEKVRLWEVT
  VTDRKTLIEPFTLLASKLSQPQSKSSFPLPGRKNKGNSNSEN

• Structural information:
  • Interpro: IPR042227  IPR027417  IPR005225  IPR001806  
  • Prosite: PS51419
  • STRING: ENSP00000393785
• Other Databases: GeneCards:  NKIRAS1  Malacards:  NKIRAS1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0007249	I-kappaB kinase/NF-kappaB signaling	IEA	biological process
GO:0005525	GTP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005575	cellular_component	ND	cellular component
GO:0003924	GTPase activity	NAS	molecular function
GO:0007249	I-kappaB kinase/NF-kappaB signaling	NAS	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)