• Gene id: 284612

Gene Summary

• Gene Symbol: SYPL2   Gene   UCSC   Ensembl
• Aliases: MG29
• Gene name: synaptophysin like 2
• Alternate names: synaptophysin-like protein 2, mitsugumin 29,
• Gene location: 1p13.3 (109466477: 109482141)     Exons: 6     NC_000001.11
• OMIM: 605333

Protein Summary

• Protein general information: Q5VXT5  
  • Name: Synaptophysin like protein 2
  • Length: 272  
  • Mass: 30156
• Sequence:

  MSSTESAGRTADKSPRQQVDRLLVGLRWRRLEEPLGFIKVLQWLFAIFAFGSCGSYSGETGAMVRCNNEAKDVSS
  IIVAFGYPFRLHRIQYEMPLCDEESSSKTMHLMGDFSAPAEFFVTLGIFSFFYTMAALVIYLRFHNLYTENKRFP
  LVDFCVTVSFTFFWLVAAAAWGKGLTDVKGATRPSSLTAAMSVCHGEEAVCSAGATPSMGLANISVLFGFINFFL
  WAGNCWFVFKETPWHGQGQGQDQDQDQDQGQGPSQESAAEQGAVEKQ

• Structural information:
  • Protein Domains: (30..23-)
    (/note="MARVEL-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00581"-)
  • Interpro: IPR008253  IPR001285  
  • Prosite: PS51225
  • STRING: ENSP00000358888
• Other Databases: GeneCards:  SYPL2  Malacards:  SYPL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0017075	syntaxin-1 binding	IBA	molecular function
GO:0030672	synaptic vesicle membrane	IBA	cellular component
GO:0008021	synaptic vesicle	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0033292	T-tubule organization	IEA	biological process
GO:0006874	cellular calcium ion homeostasis	IEA	biological process
GO:0007507	heart development	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0021762	substantia nigra development	HEP	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)