• Gene id: 284486

Gene Summary

• Gene Symbol: THEM5   Gene   UCSC   Ensembl
• Aliases: ACOT15
• Gene name: thioesterase superfamily member 5
• Alternate names: acyl-coenzyme A thioesterase THEM5, acyl-CoA thioesterase THEM5, acyl-coenzyme A thioesterase 15,
• Gene location: 1q21.3 (151853711: 151847100)     Exons: 6     NC_000001.11
• OMIM: 615653

Protein Summary

• Protein general information: Q8N1Q8  
  • Name: Acyl coenzyme A thioesterase THEM5 (Acyl CoA thioesterase THEM5) (EC 3.1.2.2) (Acyl coenzyme A thioesterase 15) (Thioesterase superfamily member 5)
  • Length: 247  
  • Mass: 27677
• Sequence:

  MIRRCFQVAARLGHHRGLLEAPRILPRLNPASAFGSSTDSMFSRFLPEKTDLKDYALPNASWCSDMLSLYQEFLE
  KTKSSGWIKLPSFKSNRDHIRGLKLPSGLAVSSDKGDCRIFTRCIQVEGQGFEYVIFFQPTQKKSVCLFQPGSYL
  EGPPGFAHGGSLAAMMDETFSKTAFLAGEGLFTLSLNIRFKNLIPVDSLVVMDVELDKIEDQKLYMSCIAHSRDQ
  QTVYAKSSGVFLQLQLEEESPQ

• Structural information:
  • Interpro: IPR029069  IPR006683  
  • PDB: 4AE7
  • PDBsum: 4AE7
  • STRING: ENSP00000357807
• Other Databases: GeneCards:  THEM5  Malacards:  THEM5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005759	mitochondrial matrix	IBA	cellular component
GO:0016290	palmitoyl-CoA hydrolase activity	IBA	molecular function
GO:0035336	long-chain fatty-acyl-CoA metabolic process	IBA	biological process
GO:0035965	cardiolipin acyl-chain remodeling	IBA	biological process
GO:0035336	long-chain fatty-acyl-CoA metabolic process	IDA	biological process
GO:0016290	palmitoyl-CoA hydrolase activity	IDA	molecular function
GO:0005759	mitochondrial matrix	IDA	cellular component
GO:0035965	cardiolipin acyl-chain remodeling	ISS	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0102991	myristoyl-CoA hydrolase activity	IEA	molecular function
GO:0016290	palmitoyl-CoA hydrolase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006637	acyl-CoA metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0035965	cardiolipin acyl-chain remodeling	IEA	biological process
GO:0005759	mitochondrial matrix	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa00062	Fatty acid elongation

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881