• Gene id: 284439

Gene Summary

• Gene Symbol: SLC25A42   Gene   UCSC   Ensembl
• Aliases: MECREN
• Gene name: solute carrier family 25 member 42
• Alternate names: mitochondrial coenzyme A transporter SLC25A42,
• Gene location: 19p13.11 (19063993: 19113029)     Exons: 10     NC_000019.10
• Gene summary(Entrez): This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial tra
• OMIM: 617497

Protein Summary

• Protein general information: Q86VD7  
  • Name: Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42)
  • Length: 318  
  • Mass: 35409
• Sequence:

  MGNGVKEGPVRLHEDAEAVLSSSVSSKRDHRQVLSSLLSGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFR
  VLYYTYLNEGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTY
  PLDLVRARMAVTPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHREYSGRRQPY
  PFERMIFGACAGLIGQSASYPLDVVRRRMQTAGVTGYPRASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVG
  ISFTTFDLMQILLRHLQS

• Structural information:
  • Interpro: IPR014762  IPR002167  IPR002067  IPR018108  IPR023395  
  • Prosite: PS50920
  • STRING: ENSP00000326693
• Other Databases: GeneCards:  SLC25A42  Malacards:  SLC25A42

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0080121	AMP transport	IDA	biological process
GO:0015867	ATP transport	IDA	biological process
GO:0015866	ADP transport	IDA	biological process
GO:0005347	ATP transmembrane transporter activity	IDA	molecular function
GO:0080122	AMP transmembrane transporter activity	IDA	molecular function
GO:0043262	adenosine-diphosphatase activity	IDA	molecular function
GO:0035349	coenzyme A transmembrane transport	IDA	biological process
GO:0015228	coenzyme A transmembrane transporter activity	IDA	molecular function
GO:0015217	ADP transmembrane transporter activity	IDA	molecular function
GO:0005739	mitochondrion	IDA	cellular component
GO:0005347	ATP transmembrane transporter activity	IEA	molecular function
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0055085	transmembrane transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq