• Gene id: 284184

Gene Summary

• Gene Symbol: NDUFAF8   Gene   UCSC   Ensembl
• Aliases: C17orf89, MC1DN34
• Gene name: NADH:ubiquinone oxidoreductase complex assembly factor 8
• Alternate names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8,
• Gene location: 17q25.3 (81239310: 81241309)     Exons: 4     NC_000017.11
• OMIM: 618461

Protein Summary

• Protein general information: A1L188  
  • Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8
  • Length: 74  
  • Mass: 7756
• Sequence:

  MSANGAVWGRVRSRLRAFPERLAACGAEAAAYGRCVQASTAPGGRLSKDFCAREFEALRSCFAAAAKKTLEGGC

• Structural information:
  • Protein Domains: (22..6-)
    (/note="CHCH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01150"-)
  • Interpro: IPR034595  
  • Prosite: PS51808
  • STRING: ENSP00000400184
• Other Databases: GeneCards:  NDUFAF8  Malacards:  NDUFAF8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005739	mitochondrion	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0032981	mitochondrial respiratory chain complex I assembly	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0032981	mitochondrial respiratory chain complex I assembly	IMP	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0032981	mitochondrial respiratory chain complex I assembly	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)