• Gene id: 284131

Gene Summary

• Gene Symbol: ENDOV   Gene   UCSC   Ensembl
• Gene name: endonuclease V
• Alternate names: endonuclease V, hEndoV, inosine-specific endoribonuclease,
• Gene location: 17q25.3 (80415116: 80438085)     Exons: 16     NC_000017.11

Protein Summary

• Protein general information: Q8N8Q3  
  • Name: Endonuclease V (hEndoV) (EC 3.1.26. ) (Inosine specific endoribonuclease)
  • Length: 282  
  • Mass: 30792
• Sequence:

  MALEAAGGPPEETLSLWKREQARLKAHVVDRDTEAWQRDPAFSGLQRVGGVDVSFVKGDSVRACASLVVLSFPEL
  EVVYEESRMVSLTAPYVSGFLAFREVPFLLELVQQLREKEPGLMPQVLLVDGNGVLHHRGFGVACHLGVLTDLPC
  VGVAKKLLQVDGLENNALHKEKIRLLQTRGDSFPLLGDSGTVLGMALRSHDRSTRPLYISVGHRMSLEAAVRLTC
  CCCRFRIPEPVRQADICSREHIRKSLGLPGPPTPRSPKAQRPVACPKGDSGESSALC

• Structural information:
  • Interpro: IPR007581  
  • CDD: cd06559
  • PDB: 4NSP 6OZE
  • PDBsum: 4NSP 6OZE
  • STRING: ENSP00000429190
• Other Databases: GeneCards:  ENDOV  Malacards:  ENDOV

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005730	nucleolus	IBA	cellular component
GO:0003727	single-stranded RNA binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IBA	molecular function
GO:0005730	nucleolus	IDA	cellular component
GO:0003677	DNA binding	IDA	molecular function
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IDA	molecular function
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IDA	molecular function
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	IDA	NOT|molecular function
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	IDA	NOT|molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0003727	single-stranded RNA binding	IDA	molecular function
GO:0003727	single-stranded RNA binding	IDA	molecular function
GO:0000287	magnesium ion binding	TAS	molecular function
GO:0004519	endonuclease activity	IEA	molecular function
GO:0006281	DNA repair	IEA	biological process
GO:0004518	nuclease activity	IEA	molecular function
GO:0004519	endonuclease activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0006281	DNA repair	IEA	biological process
GO:0000287	magnesium ion binding	IEA	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0010494	cytoplasmic stress granule	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IDA	molecular function
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	ISS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006281	DNA repair	ISS	biological process
GO:0000287	magnesium ion binding	ISS	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq