• Gene id: 284071

Gene Summary

• Gene Symbol: MEIOC   Gene   UCSC   Ensembl
• Aliases: C17orf104
• Gene name: meiosis specific with coiled-coil domain
• Alternate names: meiosis-specific coiled-coil domain-containing protein MEIOC, meiosis-specific with coiled-coil domain protein,
• Gene location: 17q21.31 (44656416: 44677085)     Exons: 9     NC_000017.11
• OMIM: 616934

Protein Summary

• Protein general information: A2RUB1  
  • Name: Meiosis specific coiled coil domain containing protein MEIOC (Meiosis specific with coiled coil domain protein)
  • Length: 952  
  • Mass: 107559
  • Tissue specificity: Expressed in fetal ovaries (PubMed
• Sequence:

  MEVRRGDTCPRPHPSGLREEGLEPKVAFPGGANRCWNLGADAGSRLTDVFGSVMLTGSASFYDCYTSQSEDNVDL
  RQTYTPFSSTEYSSSVDSSLFCAPWSTYGDDIKQPSNSQISIKNRIQTERNDYGSETDLYGLVSNILEEQDKSQP
  YFAEGTCSSNLKSVWPMNTSRFADHHDLLTETKRPIDTVISQQAFYSDESVSAMEKQYLRNSNLTPQQKIDELHH
  GFTGLDLEEQWMYPSRSDHSNCHNIQTNDTAKTTFQEYPLIKNCFTPQTGLSDIMKESGVDIYHYGRDRICTKGL
  EAPLQQKRAEMFLSQFNRYNENVDYCRYPEYVHPNKAKLNKCSNFSVQDSKKLANGTPETPTVEADTYTKLFQVK
  PANQKKMEETIPDQQNFTFPKTTPHLTEKQFAKEAVFTADFGLTSEYGLKPHTACPANDFANVTEKQQFAKPDPP
  HSEYFKSVNLLSNSATSSGGINLNRPTWMNVQTKNNTPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNL
  TPNSNLFQKYCQENPSAFSSFDFSYSGAERIQSVNHIEGLTKPGEENLFKLVTDKKIKQPNGFCDNYSAQKYGII
  ENVNKHNFQAKPQSGHYDPEEGPKHLDGLSQNTYQDLLESQGHSNSHRTRGGDNSRVNRTQVSCFSNNYMMGDLR
  HNQCFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLLSYDDLSHLYPYFNMMYGDNSFSGLMPTFGFQRPIKTRSGP
  ASELHIRLEECCEQWRALEKERKKTELALAKNYPGKKVSSTNNTPVPRLTSNPSRVDRLIVDELRELARVVTLLG
  KMERLRSSLLHASISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALASAIKEMCVATRKTRT
  ALWCALQMTLPKTASTADVVKPLQDTVNCEDKVHESINSSNPMNQRGETNKH

• Structural information:
  • Interpro: IPR027963  
  • Prosite: PS00012
  • STRING: ENSP00000386452
• Other Databases: GeneCards:  MEIOC  Malacards:  MEIOC

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0007141	male meiosis I	IBA	biological process
GO:0007144	female meiosis I	IBA	biological process
GO:0048255	mRNA stabilization	IBA	biological process
GO:0070192	chromosome organization involved in meiotic cell cycle	ISS	biological process
GO:0048599	oocyte development	ISS	biological process
GO:0007286	spermatid development	ISS	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0005634	nucleus	ISS	cellular component
GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle	ISS	biological process
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0070192	chromosome organization involved in meiotic cell cycle	IEA	biological process
GO:0048599	oocyte development	IEA	biological process
GO:0007286	spermatid development	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle	IEA	biological process
GO:0051310	metaphase plate congression	IEA	biological process
GO:0048255	mRNA stabilization	IEA	biological process
GO:0007144	female meiosis I	IEA	biological process
GO:0007141	male meiosis I	IEA	biological process
GO:0007130	synaptonemal complex assembly	IEA	biological process
GO:0006302	double-strand break repair	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)