• Gene id: 283848

Gene Summary

• Gene Symbol: CES4A   Gene   UCSC   Ensembl
• Aliases: CES6, CES8
• Gene name: carboxylesterase 4A
• Alternate names: carboxylesterase 4A, carboxylesterase 6, carboxylesterase 8 (putative),
• Gene location: 16q22.1 (66988588: 67010416)     Exons: 16     NC_000016.10
• Gene summary(Entrez): This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bon

Protein Summary

• Protein general information: Q5XG92  
  • Name: Carboxylesterase 4A (EC 3.1.1. )
  • Length: 561  
  • Mass: 63529
• Sequence:

  MRWILCWSLTLCLMAQTALGALHTKRPQVVTKYGTLQGKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPW
  KGIRDATTYPPGCLQESWGQLASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAAS
  SYEGSDLAAREKVVLVFLQHRLGIFGFLSTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAM
  SISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQILVNCLRALSGTKVMRVSNKM
  RFLQLNFQRDPEEIIWSMSPVVDGVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKET
  ITKMLWSTRTLLNITKEQVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYLYEFE
  HHARGIIVKPRTDGADHGDEMYFLFGGPFATGLSMGKEKALSLQMMKYWANFARTGNPNDGNLPCWPRYNKDEKY
  LQLDFTTRVGMKLKEKKMAFWMSLYQSQRPEKQRQF

• Structural information:
  • Interpro: IPR029058  IPR002018  IPR019826  IPR019819  
  • Prosite: PS00122 PS00941
  • STRING: ENSP00000444052
• Other Databases: GeneCards:  CES4A  Malacards:  CES4A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004771	sterol esterase activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0004806	triglyceride lipase activity	IBA	molecular function
GO:0016042	lipid catabolic process	IBA	biological process
GO:0052689	carboxylic ester hydrolase activity	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0052689	carboxylic ester hydrolase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq