• Gene id: 2831

Gene Summary

• Gene Symbol: NPBWR1   Gene   UCSC   Ensembl
• Aliases: GPR7
• Gene name: neuropeptides B and W receptor 1
• Alternate names: neuropeptides B/W receptor type 1, G-protein coupled receptor 7, neuropeptide B/W receptor 1, neuropeptides B/W receptor 1, opioid-somatostatin-like receptor 7,
• Gene location: 8q11.23 (52939181: 52943733)     Exons: 2     NC_000008.11
• OMIM: 600730

Protein Summary

• Protein general information: P48145  
  • Name: Neuropeptides B/W receptor type 1 (G protein coupled receptor 7)
  • Length: 328  
  • Mass: 36103
  • Tissue specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high le
• Sequence:

  MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLF
  ILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGR
  TYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTT
  LLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANS
  CLNPFLYAFLDASFRRNLRQLITCRAAA

• Structural information:
  • Interpro: IPR000276  IPR017452  IPR009150  IPR027348  
  • Prosite: PS00237 PS50262
  • STRING: ENSP00000330284
• Other Databases: GeneCards:  NPBWR1  Malacards:  NPBWR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016021	integral component of membrane	IC	cellular component
GO:0007218	neuropeptide signaling pathway	IBA	biological process
GO:0043005	neuron projection	IBA	cellular component
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0042277	peptide binding	IBA	molecular function
GO:0042923	neuropeptide binding	IBA	molecular function
GO:0008188	neuropeptide receptor activity	IEA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004985	opioid receptor activity	TAS	molecular function
GO:0007268	chemical synaptic transmission	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0019222	regulation of metabolic process	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0038003	opioid receptor signaling pathway	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)