• Gene id: 28232

Gene Summary

• Gene Symbol: SLCO3A1   Gene   UCSC   Ensembl
• Aliases: OATP-D, OATP-RP3, OATP3A1, OATPD, OATPRP3, SLC21A11
• Gene name: solute carrier organic anion transporter family member 3A1
• Alternate names: solute carrier organic anion transporter family member 3A1, PGE1 transporter, organic anion transporter polypeptide-related protein 3, organic anion-transporting polypeptide D, sodium-independent organic anion transporter D, solute carrier family 21 (organic a,
• Gene location: 15q26.1 (91853707: 92172434)     Exons: 16     NC_000015.10

Protein Summary

• Protein general information: Q9UIG8  
  • Name: Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide related protein 3) (OATP RP3) (OATPRP3) (Organic anion transporting polypeptide D) (OATP D) (PGE1 transporter) (Sodium independent organic anion tr
  • Length: 710  
  • Mass: 76553
  • Tissue specificity: Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at
• Sequence:

  MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQS
  ADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVC
  AANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFG
  PACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE
  QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKY
  LEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAG
  VTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPG
  KCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST
  CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTL
  DNLGRDPVPANQTHRTKFIYNLEDHEWCENMESVL

• Structural information:
  • Protein Domains: (465..51-)
    (/note="Kazal-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00798"-)
  • Interpro: IPR002350  IPR036058  IPR036259  IPR004156  
  • Prosite: PS51465
  • STRING: ENSP00000320634
• Other Databases: GeneCards:  SLCO3A1  Malacards:  SLCO3A1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IDA	cellular component
GO:0015732	prostaglandin transport	IDA	biological process
GO:0150104	transport across blood-brain barrier	NAS	biological process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	biological process
GO:0001934	positive regulation of protein phosphorylation	IMP	biological process
GO:0015347	sodium-independent organic anion transmembrane transporter activity	IBA	molecular function
GO:0043252	sodium-independent organic anion transport	IBA	biological process
GO:0015732	prostaglandin transport	IBA	biological process
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0055085	transmembrane transport	IEA	biological process
GO:0006811	ion transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0043252	sodium-independent organic anion transport	TAS	biological process
GO:0015347	sodium-independent organic anion transmembrane transporter activity	TAS	molecular function
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray