• Gene id: 28231

Gene Summary

• Gene Symbol: SLCO4A1   Gene   UCSC   Ensembl
• Aliases: OATP-E, OATP1, OATP4A1, OATPE, OATPRP1, POAT, SLC21A12
• Gene name: solute carrier organic anion transporter family member 4A1
• Alternate names: solute carrier organic anion transporter family member 4A1, OATP-RP1, colon organic anion transporter, organic anion transporter polypeptide-related protein 1, organic anion transporting polypeptide E, sodium-independent organic anion transporter E, solute carr,
• Gene location: 20q13.33 (62642057: 62690721)     Exons: 17     NC_000020.11

Protein Summary

• Protein general information: Q96BD0  
  • Name: Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide related protein 1) (OATP RP1) (OATPRP1) (POAT) (Organic anion transporting polypeptide E) (OATP E) (Sodium indepe
  • Length: 722  
  • Mass: 77193
  • Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes.
• Sequence:

  MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEV
  RYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYD
  IAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSR
  YQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELT
  TESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLS
  IWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLR
  GSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLM
  YFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALT
  ATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYK
  VLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV

• Structural information:
  • Protein Domains: (498..55-)
    (/note="Kazal-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00798"-)
  • Interpro: IPR002350  IPR036058  IPR020846  IPR036259  IPR004156  
  • Prosite: PS51465 PS50850
  • STRING: ENSP00000217159
• Other Databases: GeneCards:  SLCO4A1  Malacards:  SLCO4A1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0015349	thyroid hormone transmembrane transporter activity	IBA	molecular function
GO:0043252	sodium-independent organic anion transport	IBA	biological process
GO:0015347	sodium-independent organic anion transmembrane transporter activity	IBA	molecular function
GO:0022857	transmembrane transporter activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0055085	transmembrane transport	IEA	biological process
GO:0006811	ion transport	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0043252	sodium-independent organic anion transport	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0070327	thyroid hormone transport	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq