• Gene id: 2742

Gene Summary

• Gene Symbol: GLRA2   Gene   UCSC   Ensembl
• Aliases: GLR
• Gene name: glycine receptor alpha 2
• Alternate names: glycine receptor subunit alpha-2, glycine receptor alpha 2 subunit, glycine receptor, alpha-2 polypeptide,
• Gene location: Xp22.2 (14529297: 14731811)     Exons: 12     NC_000023.11
• Gene summary(Entrez): The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[pro
• OMIM: 604079

Protein Summary

• Protein general information: P23416  
  • Name: Glycine receptor subunit alpha 2
  • Length: 452  
  • Mass: 52002
• Sequence:

  MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTC
  NIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNK
  LLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKE
  EKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQ
  SSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGY
  GMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVH
  KK

• Structural information:
  • Interpro: IPR006028  IPR008127  IPR008129  IPR006202  IPR036734   IPR006201  IPR036719  IPR006029  IPR018000  
  • Prosite: PS00236
  • STRING: ENSP00000218075
• Other Databases: GeneCards:  GLRA2  Malacards:  GLRA2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0060079	excitatory postsynaptic potential	IEA	biological process
GO:0060079	excitatory postsynaptic potential	IEA	biological process
GO:0060078	regulation of postsynaptic membrane potential	IEA	biological process
GO:0016594	glycine binding	IDA	molecular function
GO:0007218	neuropeptide signaling pathway	IDA	biological process
GO:0016934	extracellularly glycine-gated chloride channel activity	IDA	molecular function
GO:0005230	extracellular ligand-gated ion channel activity	IEA	molecular function
GO:0006821	chloride transport	IEA	biological process
GO:0016594	glycine binding	IEA	molecular function
GO:0022824	transmitter-gated ion channel activity	IEA	molecular function
GO:0004888	transmembrane signaling receptor activity	IEA	molecular function
GO:0005216	ion channel activity	IEA	molecular function
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016934	extracellularly glycine-gated chloride channel activity	IEA	molecular function
GO:0034220	ion transmembrane transport	IEA	biological process
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0006821	chloride transport	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0034707	chloride channel complex	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0005254	chloride channel activity	IEA	molecular function
GO:1902476	chloride transmembrane transport	IBA	biological process
GO:0060012	synaptic transmission, glycinergic	IBA	biological process
GO:0050877	nervous system process	IBA	biological process
GO:0043005	neuron projection	IBA	cellular component
GO:0007268	chemical synaptic transmission	IBA	biological process
GO:0007218	neuropeptide signaling pathway	IBA	biological process
GO:0007165	signal transduction	IBA	biological process
GO:0045202	synapse	IBA	cellular component
GO:0043200	response to amino acid	IBA	biological process
GO:0042391	regulation of membrane potential	IBA	biological process
GO:0034220	ion transmembrane transport	IBA	biological process
GO:0030594	neurotransmitter receptor activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0005254	chloride channel activity	IBA	contributes to
GO:0005886	plasma membrane	TAS	cellular component
GO:0007268	chemical synaptic transmission	TAS	biological process
GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	IEA	molecular function
GO:0098690	glycinergic synapse	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:1902476	chloride transmembrane transport	IDA	biological process
GO:0022852	glycine-gated chloride ion channel activity	IDA	molecular function
GO:0034220	ion transmembrane transport	IDA	biological process
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0071361	cellular response to ethanol	IDA	biological process
GO:0071230	cellular response to amino acid stimulus	IDA	biological process
GO:0071294	cellular response to zinc ion	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R