• Gene id: 27336

Gene Summary

• Gene Symbol: HTATSF1   Gene   UCSC   Ensembl
• Aliases: TAT-SF1, TATSF1, dJ196E23.2
• Gene name: HIV-1 Tat specific factor 1
• Alternate names: HIV Tat-specific factor 1, HIV TAT specific factor 1, cofactor required for Tat activation of HIV-1 transcription,
• Gene location: Xq26.3 (136497078: 136512345)     Exons: 10     NC_000023.11
• Gene summary(Entrez): The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcr
• OMIM: 300346

Protein Summary

• Protein general information: O43719  
  • Name: HIV Tat specific factor 1 (Tat SF1)
  • Length: 755  
  • Mass: 85853
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWFPKITEDFIATYQANY
  GFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKAESGWFHVEEDRNTNVYVSGLPPDITVDEFI
  QLMSKFGIIMRDPQTEEFKVKLYKDNQGNLKGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYD
  ASKKKKKCKDYKKKLSMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ
  IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNA
  PEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAK
  ESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDL
  NKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS
  EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEE
  SDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDD
  DDDDI

• Structural information:
  • Protein Domains: (133..21-)
    (/note="RRM-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176-)
    (264..34-)
    (/note="RRM-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176"-)
  • Interpro: IPR012677  IPR035979  IPR000504  IPR034393  IPR034392  
  • Prosite: PS50102
  • CDD: cd12281
  • PDB: 2DIT 6N3D 6N3E 6N3F 6NSX
  • PDBsum: 2DIT 6N3D 6N3E 6N3F 6NSX
  • DIP: 42095
  • STRING: ENSP00000442699
• Other Databases: GeneCards:  HTATSF1  Malacards:  HTATSF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003723	RNA binding	IBA	molecular function
GO:0005684	U2-type spliceosomal complex	IBA	cellular component
GO:0005686	U2 snRNP	IBA	cellular component
GO:0000398	mRNA splicing, via spliceosome	IEA	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	TAS	cellular component
GO:0019079	viral genome replication	TAS	biological process
GO:0006357	regulation of transcription by RNA polymerase II	TAS	biological process
GO:0032784	regulation of DNA-templated transcription, elongation	TAS	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881