• Gene id: 27335

Gene Summary

• Gene Symbol: EIF3K   Gene   UCSC   Ensembl
• Aliases: ARG134, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001
• Gene name: eukaryotic translation initiation factor 3 subunit K
• Alternate names: eukaryotic translation initiation factor 3 subunit K, eIF-3 p28, eukaryotic translation initiation factor 3, subunit 12, muscle specific, muscle-specific gene M9 protein,
• Gene location: 19q13.2 (27807989: 27823013)     Exons: 3     NC_000023.11
• Gene summary(Entrez): The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of t
• OMIM: 609596

Protein Summary

• Protein general information: Q9UBQ5  
  • Name: Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle specific gene M9 protein) (PLAC 24) (eIF 3 p25) (eIF 3 p28)
  • Length: 218  
  • Mass: 25060
  • Tissue specificity: Ubiquitous, with the highest levels of expression in brain, testis and kidney. {ECO
• Sequence:

  MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALT
  NLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITY
  QHIDRWLLAEMLGDLSDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ

• Structural information:
  • Protein Domains: (42..20-)
    (/note="PCI-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01185"-)
  • Interpro: IPR016024  IPR033464  IPR009374  IPR000717  IPR016020   IPR036388  IPR036390  
  • Prosite: PS50250
  • PDB: 1RZ4 3J8B 3J8C 6FEC
  • PDBsum: 1RZ4 3J8B 3J8C 6FEC
  • DIP: 32880
  • STRING: ENSP00000248342
• Other Databases: GeneCards:  EIF3K  Malacards:  EIF3K

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005852	eukaryotic translation initiation factor 3 complex	IBA	cellular component
GO:0003743	translation initiation factor activity	IBA	contributes to
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006446	regulation of translational initiation	IEA	biological process
GO:0043022	ribosome binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IDA	biological process
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R