• Gene id: 27306

Gene Summary

• Gene Symbol: HPGDS   Gene   UCSC   Ensembl
• Aliases: GSTS, GSTS1, GSTS1-1, PGD2, PGDS
• Gene name: hematopoietic prostaglandin D synthase
• Alternate names: hematopoietic prostaglandin D synthase, GST class-sigma, epididymis secretory sperm binding protein, glutathione S-transferase sigma, glutathione-dependent PGD synthase, glutathione-dependent PGD synthetase, glutathione-requiring prostaglandin D synthase, hemato,
• Gene location: 4q22.3 (94342875: 94298534)     Exons: 6     NC_000004.12
• Gene summary(Entrez): Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can b
• OMIM: 605024

Protein Summary

• Protein general information: O60760  
  • Name: Hematopoietic prostaglandin D synthase (H PGDS) (EC 5.3.99.2) (GST class sigma) (Glutathione S transferase) (EC 2.5.1.18) (Glutathione dependent PGD synthase) (Glutathione requiring prostaglandin D synthase) (Prostaglandin H2 D isomerase)
  • Length: 199  
  • Mass: 23344
  • Tissue specificity: Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. {
• Sequence:

  MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNT
  DLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWAD
  FYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL

• Structural information:
  • Protein Domains: (2..7-)
    (/note="GST-N-terminal)
    (81..19-)
    (/note="GST-C-terminal")
  • Interpro: IPR010987  IPR036282  IPR004045  IPR004046  IPR036249  
  • Prosite: PS50405 PS50404
  • PDB: 1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E
  • PDBsum: 1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E
  • STRING: ENSP00000295256
• Other Databases: GeneCards:  HPGDS  Malacards:  HPGDS

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004364	glutathione transferase activity	IBA	molecular function
GO:0006749	glutathione metabolic process	IBA	biological process
GO:0006693	prostaglandin metabolic process	IDA	biological process
GO:0005509	calcium ion binding	IDA	molecular function
GO:0004667	prostaglandin-D synthase activity	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0006693	prostaglandin metabolic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0006633	fatty acid biosynthetic process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016853	isomerase activity	IEA	molecular function
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0001516	prostaglandin biosynthetic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0004667	prostaglandin-D synthase activity	TAS	molecular function
GO:0005737	cytoplasm	TAS	cellular component
GO:0007165	signal transduction	NAS	biological process
GO:0007626	locomotory behavior	TAS	biological process
GO:0004364	glutathione transferase activity	IEA	molecular function
GO:0004667	prostaglandin-D synthase activity	IEA	molecular function
GO:1901687	glutathione derivative biosynthetic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019371	cyclooxygenase pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:2000255	negative regulation of male germ cell proliferation	IEA	biological process
GO:0006693	prostaglandin metabolic process	IEA	biological process
GO:0004667	prostaglandin-D synthase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa05204	Chemical carcinogenesis
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00590	Arachidonic acid metabolism
hsa00480	Glutathione metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881