• Gene id: 27231

Gene Summary

• Gene Symbol: NMRK2   Gene   UCSC   Ensembl
• Aliases: ITGB1BP3, MIBP, NRK2
• Gene name: nicotinamide riboside kinase 2
• Alternate names: nicotinamide riboside kinase 2, NRK 2, RNK 2, integrin beta-1-binding protein 3, muscle-specific beta 1 integrin binding protein, nicotinic acid riboside kinase 2, nmR-K 2, ribosylnicotinamide kinase 2, ribosylnicotinic acid kinase 2,
• Gene location: 19p13.3 (3933102: 3942415)     Exons: 8     NC_000019.10
• OMIM: 618871

Protein Summary

• Protein general information: Q9NPI5  
  • Name: Nicotinamide riboside kinase 2 (NRK 2) (NmR K 2) (EC 2.7.1.22) (Integrin beta 1 binding protein 3) (Muscle integrin binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kin
  • Length: 230  
  • Mass: 26046
  • Tissue specificity: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta. {ECO
• Sequence:

  MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSS
  PQKFARAHGVSVQPEASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRSTRNYTVPDPPGLFDGHVW
  PMYQKYRQEMEANGVEVVYLDGMKSREELFREVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHRTARPAAS
  QQDSM

• Structural information:
  • Interpro: IPR027417  
  • STRING: ENSP00000480091
• Other Databases: GeneCards:  NMRK2  Malacards:  NMRK2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016301	kinase activity	IBA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0019363	pyridine nucleotide biosynthetic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0050262	ribosylnicotinamide kinase activity	IEA	molecular function
GO:0050262	ribosylnicotinamide kinase activity	EXP	molecular function
GO:0050262	ribosylnicotinamide kinase activity	EXP	molecular function
GO:0061769	ribosylnicotinate kinase activity	EXP	molecular function
GO:0061769	ribosylnicotinate kinase activity	EXP	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019674	NAD metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0045662	negative regulation of myoblast differentiation	IEA	biological process
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0009435	NAD biosynthetic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00760	Nicotinate and nicotinamide metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq