• Gene id: 27202

Gene Summary

• Gene Symbol: C5AR2   Gene   UCSC   Ensembl
• Aliases: C5L2, GPF77, GPR77
• Gene name: complement component 5a receptor 2
• Alternate names: C5a anaphylatoxin chemotactic receptor 2, C5a anaphylatoxin chemotactic receptor C5L2, G protein-coupled receptor 77, G protein-coupled receptor C5L2,
• Gene location: 19q13.32 (47331613: 47347328)     Exons: 5     NC_000019.10
• Gene summary(Entrez): This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may inst

Protein Summary

• Protein general information: Q9P296  
  • Name: C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G protein coupled receptor 77)
  • Length: 337  
  • Mass: 36080
  • Tissue specificity: Frontal cortex, hippocampus, hypothalamus, pons and liver. {ECO
• Sequence:

  MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLH
  LAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACG
  VQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLC
  WAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLR
  RSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

• Structural information:
  • Interpro: IPR001274  IPR027809  IPR000826  IPR000276  IPR017452  
  • Prosite: PS50262
  • STRING: ENSP00000472620
• Other Databases: GeneCards:  C5AR2  Malacards:  C5AR2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0004875	complement receptor activity	IBA	molecular function
GO:0002430	complement receptor mediated signaling pathway	IBA	biological process
GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	biological process
GO:0006954	inflammatory response	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0004878	complement component C5a receptor activity	IBA	molecular function
GO:0045177	apical part of cell	IDA	cellular component
GO:0009925	basal plasma membrane	IDA	cellular component
GO:2000482	regulation of interleukin-8 secretion	IMP	biological process
GO:1900165	negative regulation of interleukin-6 secretion	IMP	biological process
GO:0090024	negative regulation of neutrophil chemotaxis	IMP	biological process
GO:0032720	negative regulation of tumor necrosis factor production	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0050679	positive regulation of epithelial cell proliferation	IEA	biological process
GO:0004878	complement component C5a receptor activity	IEA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0006935	chemotaxis	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0030449	regulation of complement activation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0038178	complement component C5a signaling pathway	IEA	biological process
GO:0038178	complement component C5a signaling pathway	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881