• Gene id: 27178

Gene Summary

• Gene Symbol: IL37   Gene   UCSC   Ensembl
• Aliases: FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
• Gene name: interleukin 37
• Alternate names: interleukin-37, FIL1 zeta, IL-1 zeta, IL-1F7b (IL-1H4, IL-1H, IL-1RP1), IL-1X protein, IL1F7 (canonical product IL-1F7b), interleukin 1 family member 7, interleukin 1, zeta, interleukin-1 homolog 4, interleukin-1 superfamily z, interleukin-1-related protein, interle,
• Gene location: 2q14.1 (112908884: 112918881)     Exons: 7     NC_000022.11
• Gene summary(Entrez): The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibit
• OMIM: 605510

KEGG pathways

Pathway id	Pathway name
hsa04060	Cytokine-cytokine receptor interaction
hsa04061	Viral protein interaction with cytokine and cytokine receptor
hsa04060	Cytokine-cytokine receptor interaction
hsa04061	Viral protein interaction with cytokine and cytokine receptor

Diseases

Associated diseases	References
Rheumatoid arthritis	GAD: 20141484
Male factor infertility	MIK: 27709650
Male infertility	MIK: 27709650
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
27709650	Male infertility			150 (75 infertile men with varicocele, 75 healthy fertile controls)	Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)