• Gene id: 27175

Gene Summary

• Gene Symbol: TUBG2   Gene   UCSC   Ensembl
• Gene name: tubulin gamma 2
• Alternate names: tubulin gamma-2 chain, gamma-2-tubulin, tubulin gamma 2 chain,
• Gene location: 17q21.2 (42659283: 42667005)     Exons: 12     NC_000017.11
• OMIM: 608705

Protein Summary

• Protein general information: Q9NRH3  
  • Name: Tubulin gamma 2 chain (Gamma 2 tubulin)
  • Length: 451  
  • Mass: 51092
• Sequence:

  MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIH
  SILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLG
  SYLLERLNDRYPKKLVQTYSVFPYQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSF
  SQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
  KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSG
  LMMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDEMDRSREVVQELIDEYHAATQPDYISWGTQE
  Q

• Structural information:
  • Interpro: IPR002454  IPR008280  IPR000217  IPR018316  IPR037103   IPR036525  IPR023123  IPR017975  IPR003008  
  • Prosite: PS00227
  • CDD: cd02188
  • STRING: ENSP00000251412
• Other Databases: GeneCards:  TUBG2  Malacards:  TUBG2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007052	mitotic spindle organization	IBA	biological process
GO:0007020	microtubule nucleation	IBA	biological process
GO:0007017	microtubule-based process	IBA	biological process
GO:0005813	centrosome	IBA	cellular component
GO:0005525	GTP binding	IBA	molecular function
GO:0000278	mitotic cell cycle	IBA	biological process
GO:0005874	microtubule	IBA	cellular component
GO:0005819	spindle	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0005200	structural constituent of cytoskeleton	IBA	molecular function
GO:0000930	gamma-tubulin complex	IBA	cellular component
GO:0000226	microtubule cytoskeleton organization	IBA	biological process
GO:0000212	meiotic spindle organization	IBA	biological process
GO:0000070	mitotic sister chromatid segregation	IBA	biological process
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0007017	microtubule-based process	IEA	biological process
GO:0007020	microtubule nucleation	IEA	biological process
GO:0031122	cytoplasmic microtubule organization	IEA	biological process
GO:0000930	gamma-tubulin complex	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005525	GTP binding	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005198	structural molecule activity	TAS	molecular function
GO:0015630	microtubule cytoskeleton	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0000242	pericentriolar material	IEA	cellular component
GO:0005813	centrosome	IEA	cellular component
GO:0005881	cytoplasmic microtubule	IEA	cellular component
GO:0005876	spindle microtubule	IEA	cellular component
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0005874	microtubule	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05165	Human papillomavirus infection

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R