|
Gene id |
27122 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
DKK3 Gene UCSC Ensembl |
|
Aliases |
REIC, RIG |
|
Gene name |
dickkopf WNT signaling pathway inhibitor 3 |
|
Alternate names |
dickkopf-related protein 3, RIG-like 5-6, RIG-like 7-1, dickkopf 3 homolog, dickkopf homolog 3, dickkopf-3, dkk-3, hDkk-3, regulated in glioma, |
|
Gene location |
11p15.3 (12009826: 11962978) Exons: 12 NC_000003.12
|
|
Gene summary(Entrez) |
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is d
|
|
OMIM |
605416 |
|
| Associated diseases |
References |
| Cancer (renal cell) | GAD: 19562778 |
| Colorectal cancer | GAD: 18619730 |
| Polycystic kidney disease | GAD: 20616171 |
| Sertoli cell mediated regulation of spermatogenesis | MIK: 23667645 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Cryptorchidism | MIK: 28606200 |
| Sertoli cell mediated regulation of spermatogenesis | MIK: 23667645 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 23667645 |
Sertoli ce
ll mediate
d regulati
on of sper
matogenesi
s
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|