• Gene id: 27085

Gene Summary

• Gene Symbol: MTBP   Gene   UCSC   Ensembl
• Aliases: MDM2BP
• Gene name: MDM2 binding protein
• Alternate names: mdm2-binding protein, MDM2 (mouse double minute 2)-binding protein, 104kD, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa,
• Gene location: 8q24.12 (120445400: 120523635)     Exons: 25     NC_000008.11
• Gene summary(Entrez): This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
• OMIM: 611148

Protein Summary

• Protein general information: Q96DY7  
  • Name: Mdm2 binding protein (hMTBP)
  • Length: 904  
  • Mass: 102193
• Sequence:

  MDRYLLLVIWGEGKFPSAASREAEHGPEVSSGEGTENQPDFTAANVYHLLKRSISASINPEDSTFPACSVGGIPG
  SKKWFFAVQAIYGFYQFCSSDWQEIHFDTEKDKIEDVLQTNIEECLGAVECFEEEDSNSRESLSLADLYEEAAEN
  LHQLSDKLPAPGRAMVDIILLLSDKDPPKLKDYLPTVGALKHLREWYSAKITIAGNHCEINCQKIAEYLSANVVS
  LEDLRNVIDSKELWRGKIQIWERKFGFEISFPEFCLKGVTLKNFSTSNLNTDFLAKKIIPSKDKNILPKVFHYYG
  PALEFVQMIKLSDLPSCYMSDIEFELGLTNSTKQNSVLLLEQISSLCSKVGALFVLPCTISNILIPPPNQLSSRK
  WKEYIAKKPKTISVPDVEVKGECSSYYLLLQGNGNRRCKATLIHSANQINGSFALNLIHGKMKTKTEEAKLSFPF
  DLLSLPHFSGEQIVQREKQLANVQVLALEECLKRRKLAKQPETVSVAELKSLLVLTRKHFLDYFDAVIPKMILRK
  MDKIKTFNILNDFSPVEPNSSSLMETNPLEWPERHVLQNLETFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITL
  LDAKELLKYFTSDGLPIGDLQPLPIQKGEKTFVLTPELSPGKLQVLPFEKASVCHYHGIEYCLDDRKALERDGGF
  SELQSRLIRYETQTTCTRESFPVPTVLSPLPSPVVSSDPGSVPDGEVLQNELRTEVSRLKRRSKDLNCLYPRKRL
  VKSESSESLLSQTTGNSNHYHHHVTSRKPQTERSLPVTCPLVPIPSCETPKLATKTSSGQKSMHESKTSRQIKES
  RSQKHTRILKEVVTETLKKHSITETHECFTACSQRLFEISKFYLKDLKTSRGLFEEMKKTANNNAVQVIDWVLEK
  TSKK

• Structural information:
  • Interpro: IPR039061  IPR029418  IPR029420  IPR029421  
  • STRING: ENSP00000303398
• Other Databases: GeneCards:  MTBP  Malacards:  MTBP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031396	regulation of protein ubiquitination	IEA	biological process
GO:0007050	cell cycle arrest	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0000776	kinetochore	IDA	cellular component
GO:0000785	chromatin	IDA	cellular component
GO:0034501	protein localization to kinetochore	IMP	biological process
GO:0045839	negative regulation of mitotic nuclear division	IEA	biological process
GO:0007089	traversing start control point of mitotic cell cycle	IEA	biological process
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0000776	kinetochore	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881