• Gene id: 27076

Gene Summary

• Gene Symbol: LYPD3   Gene   UCSC   Ensembl
• Aliases: C4.4A
• Gene name: LY6/PLAUR domain containing 3
• Alternate names: ly6/PLAUR domain-containing protein 3, 2310061G07Rik, GPI-anchored metastasis-associated protein C4.4A homolog, GPI-anchored metastasis-associated protein homolog, MIG-C4, matrigel-induced gene C4 protein,
• Gene location: 19q13.31 (43465607: 43460786)     Exons: 5     NC_000019.10
• OMIM: 612888

Protein Summary

• Protein general information: O95274  
  • Name: Ly6/PLAUR domain containing protein 3 (GPI anchored metastasis associated protein C4.4A homolog) (Matrigel induced gene C4 protein) (MIG C4)
  • Length: 346  
  • Mass: 35971
  • Tissue specificity: Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional
• Sequence:

  MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQF
  SLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREA
  CQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDL
  RNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGA
  AGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL

• Structural information:
  • Protein Domains: (33..12-)
    (/note="UPAR/Ly6-1)
    (140..22-)
    (/note="UPAR/Ly6-2")
  • Interpro: IPR016054  
  • PDB: 6IOM 6ION
  • PDBsum: 6IOM 6ION
  • STRING: ENSP00000244333
• Other Databases: GeneCards:  LYPD3  Malacards:  LYPD3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046658	anchored component of plasma membrane	TAS	cellular component
GO:0007160	cell-matrix adhesion	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0043236	laminin binding	IBA	molecular function
GO:0031225	anchored component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0007160	cell-matrix adhesion	IEA	biological process
GO:0043236	laminin binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005615	extracellular space	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881