• Gene id: 26471

Gene Summary

• Gene Symbol: NUPR1   Gene   UCSC   Ensembl
• Aliases: COM1, P8
• Gene name: nuclear protein 1, transcriptional regulator
• Alternate names: nuclear protein 1, candidate of metastasis 1, nuclear protein, transcriptional regulator, 1, nuclear transcriptional regulator protein 1, protein p8,
• Gene location: 16p11.2 (28538973: 28532707)     Exons: 3     NC_000016.10
• OMIM: 614812

Protein Summary

• Protein general information: O60356  
  • Name: Nuclear protein 1 (Candidate of metastasis 1) (Protein p8)
  • Length: 82  
  • Mass: 8873
  • Tissue specificity: Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lym
• Sequence:

  MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSER
  KKRGARR

• Structural information:
  • Interpro: IPR018792  
  • DIP: 61114
• Other Databases: GeneCards:  NUPR1  Malacards:  NUPR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008285	negative regulation of cell population proliferation	IBA	biological process
GO:0045786	negative regulation of cell cycle	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0003677	DNA binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISS	biological process
GO:0043433	negative regulation of DNA-binding transcription factor activity	ISS	biological process
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISS	biological process
GO:0010698	acetyltransferase activator activity	ISS	molecular function
GO:0150078	positive regulation of neuroinflammatory response	ISS	biological process
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	biological process
GO:0010506	regulation of autophagy	ISS	biological process
GO:0050680	negative regulation of epithelial cell proliferation	ISS	biological process
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:0062099	negative regulation of programmed necrotic cell death	IMP	biological process
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	IMP	biological process
GO:0043433	negative regulation of DNA-binding transcription factor activity	IMP	biological process
GO:1902902	negative regulation of autophagosome assembly	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:1904691	negative regulation of type B pancreatic cell proliferation	ISS	biological process
GO:0010507	negative regulation of autophagy	ISS	biological process
GO:0010507	negative regulation of autophagy	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0010507	negative regulation of autophagy	IMP	biological process
GO:1905897	regulation of response to endoplasmic reticulum stress	ISS	biological process
GO:0043525	positive regulation of neuron apoptotic process	ISS	biological process
GO:1904036	negative regulation of epithelial cell apoptotic process	ISS	biological process
GO:0045820	negative regulation of glycolytic process	IMP	biological process
GO:1903862	positive regulation of oxidative phosphorylation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0045786	negative regulation of cell cycle	IMP	biological process
GO:1901800	positive regulation of proteasomal protein catabolic process	IMP	biological process
GO:0003713	transcription coactivator activity	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1905897	regulation of response to endoplasmic reticulum stress	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0003682	chromatin binding	IEA	molecular function
GO:0006473	protein acetylation	IEA	biological process
GO:0009636	response to toxic substance	IEA	biological process
GO:0010698	acetyltransferase activator activity	IEA	molecular function
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA	biological process
GO:0050680	negative regulation of epithelial cell proliferation	IEA	biological process
GO:0150078	positive regulation of neuroinflammatory response	IEA	biological process
GO:0002526	acute inflammatory response	IEA	biological process
GO:0008584	male gonad development	IEA	biological process
GO:0010507	negative regulation of autophagy	IEA	biological process
GO:0031401	positive regulation of protein modification process	IEA	biological process
GO:0035914	skeletal muscle cell differentiation	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0045786	negative regulation of cell cycle	IEA	biological process
GO:0048147	negative regulation of fibroblast proliferation	IEA	biological process
GO:0065003	protein-containing complex assembly	IEA	biological process
GO:1904036	negative regulation of epithelial cell apoptotic process	IEA	biological process
GO:1904691	negative regulation of type B pancreatic cell proliferation	IEA	biological process
GO:2000194	regulation of female gonad development	IEA	biological process
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0043085	positive regulation of catalytic activity	IEA	biological process
GO:0043085	positive regulation of catalytic activity	IEA	biological process
GO:1903508	positive regulation of nucleic acid-templated transcription	IEA	biological process
GO:0003677	DNA binding	IDA	molecular function
GO:0032993	protein-DNA complex	IDA	cellular component
GO:0045787	positive regulation of cell cycle	IDA	biological process
GO:0005634	nucleus	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05202	Transcriptional misregulation in cancer

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)