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Gene id 26289
Gene Summary    Protein Summary    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol AK5   Gene   UCSC   Ensembl
Aliases AK6
Gene name adenylate kinase 5
Alternate names adenylate kinase isoenzyme 5, AK 5, ATP-AMP transphosphorylase 5, adenylate kinase 6,
Gene location 1p31.1 (77281907: 77559965)     Exons: 16     NC_000001.11
Gene summary(Entrez) This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the
OMIM 608009

Protein Summary

Protein general information Q9Y6K8  

Name: Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP AMP transphosphorylase 5)

Length: 562  Mass: 63333

Tissue specificity: Brain specific. {ECO

Sequence MNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQS
RRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSL
KIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVA
QALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDA
DRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRK
CKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVA
SLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRAS
IPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIF
Structural information
Interpro:  IPR000850  IPR033690  IPR006267  IPR027417  
Prosite:   PS00113
CDD:   cd01428

PDB:  
2BWJ
PDBsum:   2BWJ
STRING:   ENSP00000346577
Other Databases GeneCards:  AK5  Malacards:  AK5

KEGG pathways

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Pathway idPathway name
hsa01100Metabolic pathways
hsa00230Purine metabolism
hsa00730Thiamine metabolism
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Cryptorchidism MIK: 28606200
Teratozoospermia MIK: 17327269
Unexplained infertility MIK: 25753583

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract
28606200 Cryptorchi
dism

Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
Male infertility MeDIP-Seq
Show abstract
25753583 Unexplaine
d infertil
ity

46 (17 fertile
men, 29 male pa
tients)
Male infertility Microarray
Show abstract