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Gene id 26167
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol PCDHB5   Gene   UCSC   Ensembl
Aliases PCDH-BETA5
Gene name protocadherin beta 5
Alternate names protocadherin beta-5, PCDH-beta-5,
Gene location 5q31.3 (141135205: 141138614)     Exons: 1     NC_000005.10
Gene summary(Entrez) This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.
OMIM 603005

Protein Summary

Protein general information Q9Y5E4  

Name: Protocadherin beta 5 (PCDH beta 5)

Length: 795  Mass: 86423

Sequence METALAKTPQKRQVMFLAILLLLWEAGSEAVRYSIPEETESGYSVANLAKDLGLGVGELATRGARMHYKGNKELL
QLDIKTGNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLKIPESTQPGT
VFPLKIAQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGT
TTIRIVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEI
RLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVAVFSVSDPDSG
DNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVNDNAPAF
TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNGHLFALRSLDYEALQA
FEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW
LSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEA
APAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSGTGTLSQSYHY
EVCLTGDSGAGEFKFLKPIIPNLLPQGAGEEIGKTAAFRNSFGLN
Structural information
Protein Domains
(35..13-)
(/note="Cadherin-1)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00043-)
(138..24-)
(/note="Cadherin-2)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00043-)
(247..34-)
(/note="Cadherin-3)
(/evidence="ECO:0000255|PROSITE-ProRule:-)
Interpro:  IPR002126  IPR015919  IPR032455  IPR020894  IPR013164  
IPR030730  
Prosite:   PS00232 PS50268
STRING:   ENSP00000231134
Other Databases GeneCards:  PCDHB5  Malacards:  PCDHB5

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0005887 integral component of pla
sma membrane
IBA cellular component
GO:0007155 cell adhesion
IBA biological process
GO:0005509 calcium ion binding
IEA molecular function
GO:0005886 plasma membrane
IEA cellular component
GO:0007155 cell adhesion
IEA biological process
GO:0007156 homophilic cell adhesion
via plasma membrane adhes
ion molecules
IEA biological process
GO:0016020 membrane
IEA cellular component
GO:0016020 membrane
IEA cellular component
GO:0005886 plasma membrane
IEA cellular component
GO:0007155 cell adhesion
IEA biological process
GO:0016021 integral component of mem
brane
IEA cellular component
GO:0005886 plasma membrane
IEA cellular component
GO:0045202 synapse
IEA cellular component
GO:0016339 calcium-dependent cell-ce
ll adhesion via plasma me
mbrane cell adhesion mole
cules
NAS biological process
GO:0007416 synapse assembly
TAS biological process
GO:0007268 chemical synaptic transmi
ssion
TAS biological process
GO:0016021 integral component of mem
brane
NAS cellular component
Associated diseases References
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract