• Gene id: 26155

Gene Summary

• Gene Symbol: NOC2L   Gene   UCSC   Ensembl
• Aliases: NET15, NET7, NIR, PPP1R112
• Gene name: NOC2 like nucleolar associated transcriptional repressor
• Alternate names: nucleolar complex protein 2 homolog, NOC2-like protein, NOC2L nucleolar associated transcriptional repressor, novel INHAT (inhibitor of histone acetyltransferase) repressor, novel INHAT repressor, nucleolar complex associated 2 homolog, protein NOC2 homolog, pro,
• Gene location: 1p36.33 (959255: 944202)     Exons: 19     NC_000001.11
• Gene summary(Entrez): Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 200
• OMIM: 118920

Protein Summary

• Protein general information: Q9Y3T9  
  • Name: Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2 like protein) (Novel INHAT repressor)
  • Length: 749  
  • Mass: 84919
• Sequence:

  MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSPDKPGGSPSASRRKGRASEHKDQLSR
  LKDRDPEFYKFLQENDQSLLNFSDSDSSEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVT
  VAMVERWKQAAKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGCLQKLLFG
  KVAKDSSRMLQPSSSPLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVI
  VWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQ
  HAFLYIRQLAIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTAR
  FYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQEKAYRDGLVEQ
  LYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQA
  VEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKRRKMADRKDEDRKQFKDLFDLNSSEE
  DDTEGFSERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDELEDLQLSEDD

• Structural information:
  • Interpro: IPR016024  IPR005343  
  • STRING: ENSP00000317992
• Other Databases: GeneCards:  NOC2L  Malacards:  NOC2L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005654	nucleoplasm	IBA	cellular component
GO:0005730	nucleolus	IBA	cellular component
GO:0030691	Noc2p-Noc3p complex	IBA	cellular component
GO:0035067	negative regulation of histone acetylation	IBA	biological process
GO:0042273	ribosomal large subunit biogenesis	IBA	biological process
GO:0042393	histone binding	IBA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	biological process
GO:0003714	transcription corepressor activity	IBA	molecular function
GO:0030690	Noc1p-Noc2p complex	IBA	cellular component
GO:0070491	repressing transcription factor binding	IBA	molecular function
GO:0070491	repressing transcription factor binding	IDA	molecular function
GO:0034644	cellular response to UV	IDA	biological process
GO:0031491	nucleosome binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0003714	transcription corepressor activity	IDA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	biological process
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	biological process
GO:0042393	histone binding	IDA	molecular function
GO:0035067	negative regulation of histone acetylation	IDA	biological process
GO:0005730	nucleolus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0002903	negative regulation of B cell apoptotic process	IMP	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006915	apoptotic process	IEA	biological process
GO:1901796	regulation of signal transduction by p53 class mediator	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005654	nucleoplasm	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0031497	chromatin assembly	IDA	biological process
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IMP	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq