• Gene id: 26063

Gene Summary

• Gene Symbol: DECR2   Gene   UCSC   Ensembl
• Aliases: PDCR, SDR17C1
• Gene name: 2,4-dienoyl-CoA reductase 2
• Alternate names: peroxisomal 2,4-dienoyl-CoA reductase, 2,4-dienoyl-CoA reductase 2, peroxisomal, short chain dehydrogenase/reductase family 17C member 1,
• Gene location: 16p13.3 (401884: 412481)     Exons: 9     NC_000016.10

Protein Summary

• Protein general information: Q9NUI1  
  • Name: Peroxisomal 2,4 dienoyl CoA reductase (pDCR) (EC 1.3.1.34) (2,4 dienoyl CoA reductase 2) (Short chain dehydrogenase/reductase family 17C member 1)
  • Length: 292  
  • Mass: 30778
• Sequence:

  MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGA
  TGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYE
  KFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQA
  SLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL

• Structural information:
  • Interpro: IPR036291  IPR002347  
  • PDB: 4FC6 4FC7
  • PDBsum: 4FC6 4FC7
  • STRING: ENSP00000219481
• Other Databases: GeneCards:  DECR2  Malacards:  DECR2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005777	peroxisome	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	IEA	molecular function
GO:0005778	peroxisomal membrane	TAS	cellular component
GO:0005778	peroxisomal membrane	TAS	cellular component
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006625	protein targeting to peroxisome	TAS	biological process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005777	peroxisome	IEA	cellular component
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	IDA	molecular function
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	IDA	molecular function
GO:0006636	unsaturated fatty acid biosynthetic process	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04146	Peroxisome

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq