• Gene id: 260425

Gene Summary

• Gene Symbol: MAGI3   Gene   UCSC   Ensembl
• Aliases: MAGI-3, dJ730K3.2
• Gene name: membrane associated guanylate kinase, WW and PDZ domain containing 3
• Alternate names: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3, membrane-associated guanylate kinase inverted 3, membrane-associated guanylate kinase-related 3,
• Gene location: 1p13.2 (113390473: 113685922)     Exons: 23     NC_000001.11
• OMIM: 601711

Protein Summary

• Protein general information: Q5TCQ9  
  • Name: Membrane associated guanylate kinase, WW and PDZ domain containing protein 3 (Membrane associated guanylate kinase inverted 3) (MAGI 3)
  • Length: 1481  
  • Mass: 162949
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVN
  GTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAP
  RDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTS
  VSKMERMDSSLPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE
  MAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAK
  RKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGK
  IAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETC
  MNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK
  VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAG
  SLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSI
  YIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAF
  ISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG
  DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSA
  LEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRL
  AEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVIYD
  EQSPLPPSSHFASIFEESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSH
  GHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSKGENKSCQVSTRAGSG
  QDQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSR
  TRSPEKKIKRMVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVVSNKTE
  DHKGKELEAADKNKETGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGMAEKRQ

• Structural information:
  • Protein Domains: (18..10-)
    (/note="PDZ-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00143-)
    (114..28-)
    (/note="Guanylate-kinase-like)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00100-)
    (293..32-)
    (/note="WW-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:-)
  • Interpro: IPR008145  IPR008144  IPR020590  IPR030035  IPR027417   IPR001478  IPR041489  IPR036034  IPR001202  IPR036020  
  • Prosite: PS00856 PS50052 PS50106 PS01159 PS50020
  • CDD: cd00201
  • PDB: 3SOE
  • PDBsum: 3SOE
  • STRING: ENSP00000304604
• Other Databases: GeneCards:  MAGI3  Malacards:  MAGI3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0005911	cell-cell junction	IBA	cellular component
GO:0007165	signal transduction	IBA	biological process
GO:0004385	guanylate kinase activity	NAS	molecular function
GO:0016020	membrane	NAS	cellular component
GO:0006915	apoptotic process	NAS	biological process
GO:0005911	cell-cell junction	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0046328	regulation of JNK cascade	IEA	biological process
GO:0060090	molecular adaptor activity	IEA	molecular function
GO:0005923	bicellular tight junction	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0016032	viral process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005923	bicellular tight junction	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0030054	cell junction	IDA	cellular component
GO:0046710	GDP metabolic process	IEA	biological process
GO:0046037	GMP metabolic process	IEA	biological process
GO:0035556	intracellular signal transduction	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04015	Rap1 signaling pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R