• Gene id: 26034

Gene Summary

• Gene Symbol: IPCEF1   Gene   UCSC   Ensembl
• Aliases: PIP3-E
• Gene name: interaction protein for cytohesin exchange factors 1
• Alternate names: interactor protein for cytohesin exchange factors 1, interaction protein for cytohesin exchange factors 1 Interaction protein for cytohesin exchange factors 1, phosphoinositide-binding protein PIP3-E,
• Gene location: 6q25.2 (154356765: 154154482)     Exons: 14     NC_000006.12

Protein Summary

• Protein general information: Q8WWN9  
  • Name: Interactor protein for cytohesin exchange factors 1 (Phosphoinositide binding protein PIP3 E)
  • Length: 437  
  • Mass: 48993
• Sequence:

  MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLY
  WYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEE
  CYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTV
  NSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIM
  DKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAM
  INQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI

• Structural information:
  • Protein Domains: (41..14-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145"-)
  • Interpro: IPR011993  IPR001849  
  • Prosite: PS50003
  • PDB: 5MR1
  • PDBsum: 5MR1
  • STRING: ENSP00000394751
• Other Databases: GeneCards:  IPCEF1  Malacards:  IPCEF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0019904	protein domain specific binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0015671	oxygen transport	NAS	biological process
GO:0005344	oxygen carrier activity	NAS	molecular function
GO:0004601	peroxidase activity	ISS	molecular function
GO:0006979	response to oxidative stress	ISS	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq