Male Infertility Database

Search Result

Gene id

26030

Gene Summary Protein Summary Gene ontology Diseases PubMed

Gene Summary

Gene Symbol

PLEKHG3 Gene UCSC Ensembl

Aliases

ARHGEF43, KIAA0599

Gene name

pleckstrin homology and RhoGEF domain containing G3

Alternate names

pleckstrin homology domain-containing family G member 3, PH domain-containing family G member 3, pleckstrin homology domain containing, family G (with RhoGef domain) member 3, pleckstrin homology domain containing, family G, member 3,

Gene location

14q23.3 (64704127: 64750248) Exons: 25 NC_000014.9

OMIM

617940

Protein Summary

Protein general information

A1L390

Name: Pleckstrin homology domain containing family G member 3 (PH domain containing family G member 3)

Length: 1219 Mass: 134412

Sequence

MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPNSNNNSSSWLNVKGPL
SPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIENIYALNS
QLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLL
KPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTY
GELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQ
AKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEP
TKHLLRQLNEKARAAGMKGKGRRESESSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEG
PSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQEPESLLPPSVLD
QASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGSEKGLARHGSATDSLSCQLSPEVDISVGV
ATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLV
RNSISRFNSLPRPDPEPVPPVGSKRQVGSRPTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSG
GSPGKGPGQGQANGFDLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQGELV
APLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDGKSPTVPCLQEEAGEP
LGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFFFNPSAVSQRTTSPGGRPSARSPLSPTETFSWPDV
RELCSKYASRDEARRAGGGRPRGPPVNRSHSVPENMVEPPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPD
GGETLYVTADLTLEDNRRVIVMEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDPADPS
QQGRVRNLREKFQALNSVG

Structural information

Protein Domains	(93..27-) (/note="DH-) (/evidence="ECO:0000255\|PROSITE-ProRule:PRU00062-) (296..39-) (/note="PH-) (/evidence="ECO:0000255\|PROSITE-ProRule:PRU00145"-)
Interpro:	IPR035899 IPR000219 IPR011993 IPR001849
Prosite:	PS50010 PS50003
CDD:	cd00160
STRING:	ENSP00000247226

Other Databases

GeneCards: PLEKHG3 Malacards: PLEKHG3

Gene ontology

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GO accession	Term name	Evidence code	Go category
GO:0005089	Rho guanyl-nucleotide exc hange factor activity	IBA	molecular function
GO:0005085	guanyl-nucleotide exchang e factor activity	IEA	molecular function

Diseases

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Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

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PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
17327269	Teratozoos permia	19 (6 controls , 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)	Show abstract
28606200	Cryptorchi dism	Monozgotic twin s (1 control, I cwith cryptorc hidism)	Male infertility	MeDIP-Seq	Show abstract
31037746	Spermatoge nic defect s	28 men with az oospermia	Male infertility	Microarray	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

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Gene Summary

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Diseases

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

Protein Summary

Gene ontology

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Diseases Expand All | Collapse All

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PubMed references

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Diseases

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