• Gene id: 26001

Gene Summary

• Gene Symbol: RNF167   Gene   UCSC   Ensembl
• Aliases: 5730408C10Rik, LP2254, RING105
• Gene name: ring finger protein 167
• Alternate names: E3 ubiquitin-protein ligase RNF167, RING-type E3 ubiquitin transferase RNF167,
• Gene location: 17p13.2 (38264572: 38292614)     Exons: 7     NC_000019.10
• Gene summary(Entrez): RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]
• OMIM: 610431

Protein Summary

• Protein general information: Q9H6Y7  
  • Name: E3 ubiquitin protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) (RING type E3 ubiquitin transferase RNF167) (RING105)
  • Length: 350  
  • Mass: 38299
  • Tissue specificity: Strongly expressed in the kidney and liver (at protein level). {ECO
• Sequence:

  MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIAPPPP
  APVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRA
  LFVYEKGARVLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGD
  QYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPR
  DHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV

• Structural information:
  • Protein Domains: (49..15-)
    (/note="PA"-)
  • Interpro: IPR003137  IPR001841  IPR011016  IPR013083  
  • Prosite: PS50089
  • STRING: ENSP00000262482
• Other Databases: GeneCards:  RNF167  Malacards:  RNF167

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061630	ubiquitin protein ligase activity	IBA	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0045786	negative regulation of cell cycle	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0008270	zinc ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0012505	endomembrane system	IEA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process
GO:0004842	ubiquitin-protein transferase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0000209	protein polyubiquitination	IDA	biological process
GO:0045786	negative regulation of cell cycle	IMP	biological process
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881