• Gene id: 25976

Gene Summary

• Gene Symbol: TIPARP   Gene   UCSC   Ensembl
• Aliases: ARTD14, PARP7, pART14
• Gene name: TCDD inducible poly(ADP-ribose) polymerase
• Alternate names: protein mono-ADP-ribosyltransferase TIPARP, ADP-ribosyltransferase diphtheria toxin-like 14, poly [ADP-ribose] polymerase 7,
• Gene location: 3q25.31 (156674589: 156706769)     Exons: 8     NC_000003.12
• Gene summary(Entrez): This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in m
• OMIM: 612480

Protein Summary

• Protein general information: Q7Z3E1  
  • Name: Protein mono ADP ribosyltransferase TIPARP (EC 2.4.2. ) (ADP ribosyltransferase diphtheria toxin like 14) (ARTD14) (Poly [ADP ribose] polymerase 7) (PARP 7) (TCDD inducible poly [ADP ribose] polymerase)
  • Length: 657  
  • Mass: 76227
• Sequence:

  MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPILNTLLESGSLDGVFRS
  RNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGT
  VADSTPAHFQTDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFE
  LVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
  MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRG
  LKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYP
  ETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRII
  NERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
  HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI

• Structural information:
  • Protein Domains: (332..41-)
    (/note="WWE-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00248-)
    (449..65-)
    (/note="PARP-catalytic)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00397"-)
  • Interpro: IPR012317  IPR004170  IPR037197  IPR000571  
  • Prosite: PS51059 PS50918 PS50103
  • STRING: ENSP00000420612
• Other Databases: GeneCards:  TIPARP  Malacards:  TIPARP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006471	protein ADP-ribosylation	IDA	biological process
GO:1990404	protein ADP-ribosylase activity	IDA	molecular function
GO:0140289	protein mono-ADP-ribosylation	IDA	biological process
GO:1990404	protein ADP-ribosylase activity	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0070213	protein auto-ADP-ribosylation	IDA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0071407	cellular response to organic cyclic compound	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA	molecular function
GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	molecular function
GO:0045732	positive regulation of protein catabolic process	IMP	biological process
GO:0010629	negative regulation of gene expression	IMP	biological process
GO:0060325	face morphogenesis	IEA	biological process
GO:0048745	smooth muscle tissue development	IEA	biological process
GO:0048705	skeletal system morphogenesis	IEA	biological process
GO:0009791	post-embryonic development	IEA	biological process
GO:0008585	female gonad development	IEA	biological process
GO:0006807	nitrogen compound metabolic process	IEA	biological process
GO:0006471	protein ADP-ribosylation	IEA	biological process
GO:0001822	kidney development	IEA	biological process
GO:0001570	vasculogenesis	IEA	biological process
GO:0060021	roof of mouth development	IEA	biological process
GO:0048008	platelet-derived growth factor receptor signaling pathway	IEA	biological process
GO:0030097	hemopoiesis	IEA	biological process
GO:0008210	estrogen metabolic process	IEA	biological process
GO:0008209	androgen metabolic process	IEA	biological process
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:1904612	response to 2,3,7,8-tetrachlorodibenzodioxine	IEA	biological process
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)