• Gene id: 259307

Gene Summary

• Gene Symbol: IL4I1   Gene   UCSC   Ensembl
• Aliases: FIG1, LAAO, LAO
• Gene name: interleukin 4 induced 1
• Alternate names: L-amino-acid oxidase, Fig-1 protein, IL4-induced protein 1, interleukin four induced 1,
• Gene location: 19q13.33 (49929538: 49889653)     Exons: 12     NC_000009.12
• Gene summary(Entrez): This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced
• OMIM: 609742

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01100	Metabolic pathways
hsa00250	Alanine, aspartate and glutamate metabolism
hsa00380	Tryptophan metabolism
hsa00280	Valine, leucine and isoleucine degradation
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis
hsa00360	Phenylalanine metabolism
hsa00350	Tyrosine metabolism
hsa00270	Cysteine and methionine metabolism

Diseases

Associated diseases	References
Role in sperm function	MIK: 25767141
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Role in sperm function	MIK: 25767141
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25767141	Role in sperm function				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray