• Gene id: 25874

Gene Summary

• Gene Symbol: MPC2   Gene   UCSC   Ensembl
• Aliases: BRP44, SLC54A2
• Gene name: mitochondrial pyruvate carrier 2
• Alternate names: mitochondrial pyruvate carrier 2, brain protein 44,
• Gene location: 1q24.2 (167937071: 167916674)     Exons: 7     NC_000001.11
• OMIM: 614737

Protein Summary

• Protein general information: O95563  
  • Name: Mitochondrial pyruvate carrier 2 (Brain protein 44)
  • Length: 127  
  • Mass: 14279
• Sequence:

  MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVL
  MATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

• Structural information:
  • Interpro: IPR005336  
  • STRING: ENSP00000356820
• Other Databases: GeneCards:  MPC2  Malacards:  MPC2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006850	mitochondrial pyruvate transmembrane transport	IBA	biological process
GO:0031305	integral component of mitochondrial inner membrane	IBA	cellular component
GO:0050833	pyruvate transmembrane transporter activity	IBA	molecular function
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0006850	mitochondrial pyruvate transmembrane transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA	biological process
GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate	IEA	biological process
GO:0050833	pyruvate transmembrane transporter activity	IEA	molecular function
GO:0006850	mitochondrial pyruvate transmembrane transport	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray