• Gene id: 25840

Gene Summary

• Gene Symbol: METTL7A   Gene   UCSC   Ensembl
• Aliases: AAM-B, AAMB
• Gene name: methyltransferase like 7A
• Alternate names: methyltransferase-like protein 7A, protein AAM-B,
• Gene location: 12q13.12 (50925014: 50932507)     Exons: 2     NC_000012.12
• OMIM: 618338

Protein Summary

• Protein general information: Q9H8H3  
  • Name: Methyltransferase like protein 7A (EC 2.1.1. ) (Protein AAM B)
  • Length: 244  
  • Mass: 28319
• Sequence:

  MELTIFILRLAIYILTFPLYLLNFLGLWSWICKKWFPYFLVRFTVIYNEQMASKKRELFSNLQEFAGPSGKLSLL
  EVGCGTGANFKFYPPGCRVTCIDPNPNFEKFLIKSIAENRHLQFERFVVAAGENMHQVADGSVDVVVCTLVLCSV
  KNQERILREVCRVLRPGGAFYFMEHVAAECSTWNYFWQQVLDPAWHLLFDGCNLTRESWKALERASFSKLKLQHI
  QAPLSWELVRPHIYGYAVK

• Structural information:
  • Interpro: IPR013216  IPR029063  
  • STRING: ENSP00000448785
• Other Databases: GeneCards:  METTL7A  Malacards:  METTL7A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008168	methyltransferase activity	IBA	molecular function
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005811	lipid droplet	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904724	tertiary granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005811	lipid droplet	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005811	lipid droplet	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray