• Gene id: 25798

Gene Summary

• Gene Symbol: BRI3   Gene   UCSC   Ensembl
• Aliases: I3
• Gene name: brain protein I3
• Alternate names: brain protein I3, pRGR2,
• Gene location: 7q21.3 (98281672: 98322397)     Exons: 8     NC_000007.14
• OMIM: 615628

Protein Summary

• Protein general information: O95415  
  • Name: Brain protein I3 (pRGR2)
  • Length: 125  
  • Mass: 13645
• Sequence:

  MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIHSRTVTRYPANSIVVV
  GGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNCGATFA

• Structural information:
  • Interpro: IPR019317  
  • STRING: ENSP00000297290
• Other Databases: GeneCards:  BRI3  Malacards:  BRI3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005764	lysosome	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0042802	identical protein binding	IDA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0035577	azurophil granule membrane	TAS	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005765	lysosomal membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq