• Gene id: 25797

Gene Summary

• Gene Symbol: QPCT   Gene   UCSC   Ensembl
• Aliases: GCT, QC, sQC
• Gene name: glutaminyl-peptide cyclotransferase
• Alternate names: glutaminyl-peptide cyclotransferase, EC, glutaminyl cyclase, glutaminyl-tRNA cyclotransferase, glutamyl cyclase,
• Gene location: 2p22.2 (37344629: 37373321)     Exons: 7     NC_000002.12
• Gene summary(Entrez): This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided b
• OMIM: 607065

Protein Summary

• Protein general information: Q16769  
  • Name: Glutaminyl peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl tRNA cyclotransferase) (Glutamyl cyclase) (EC)
  • Length: 361  
  • Mass: 40877
• Sequence:

  MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLI
  ERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWN
  NRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMAS
  TPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
  GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL

• Structural information:
  • Interpro: IPR037457  IPR007484  
  • CDD: cd03880
  • PDB: 1MOI 2AFM 2AFO 2AFS 2AFU 2AFW 2AFX 2AFZ 2ZED 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP 3PBB 3PBE 3SI0 4YU9 4YWY 6GBX
  • PDBsum: 1MOI 2AFM 2AFO 2AFS 2AFU 2AFW 2AFX 2AFZ 2ZED 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP 3PBB 3PBE 3SI0 4YU9 4YWY 6GBX
  • STRING: ENSP00000344829
• Other Databases: GeneCards:  QPCT  Malacards:  QPCT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	IBA	biological process
GO:0016603	glutaminyl-peptide cyclotransferase activity	IBA	molecular function
GO:0008270	zinc ion binding	IBA	molecular function
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	IDA	biological process
GO:0016603	glutaminyl-peptide cyclotransferase activity	IDA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0016603	glutaminyl-peptide cyclotransferase activity	IEA	molecular function
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0006464	cellular protein modification process	TAS	biological process
GO:0016603	glutaminyl-peptide cyclotransferase activity	IEA	molecular function
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904724	tertiary granule lumen	TAS	cellular component
GO:1904813	ficolin-1-rich granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0035580	specific granule lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq