• Gene id: 25796

Gene Summary

• Gene Symbol: PGLS   Gene   UCSC   Ensembl
• Aliases: 6PGL, HEL-S-304
• Gene name: 6-phosphogluconolactonase
• Alternate names: 6-phosphogluconolactonase, epididymis secretory protein Li 304, epididymis secretory sperm binding protein,
• Gene location: 19p13.11 (17511648: 17521290)     Exons: 6     NC_000019.10
• OMIM: 613891

Protein Summary

• Protein general information: O95336  
  • Name: 6 phosphogluconolactonase (6PGL) (EC 3.1.1.31)
  • Length: 258  
  • Mass: 27547
• Sequence:

  MAAPAPGLISVFSSSQELGAALAQLVAQRAACCLAGARARFALGLSGGSLVSMLARELPAAVAPAGPASLARWTL
  GFCDERLVPFDHAESTYGLYRTHLLSRLPIPESQVITINPELPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVG
  PDGHTCSLFPDHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLP
  AALVQPHTGKLCWFLDEAAARLLTVPFEKHSTL

• Structural information:
  • Interpro: IPR005900  IPR006148  IPR037171  IPR039104  
  • CDD: cd01400
  • STRING: ENSP00000252603
• Other Databases: GeneCards:  PGLS  Malacards:  PGLS

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0017057	6-phosphogluconolactonase activity	IBA	molecular function
GO:0009051	pentose-phosphate shunt, oxidative branch	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0006098	pentose-phosphate shunt	IEA	biological process
GO:0017057	6-phosphogluconolactonase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0017057	6-phosphogluconolactonase activity	IEA	molecular function
GO:0017057	6-phosphogluconolactonase activity	EXP	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006098	pentose-phosphate shunt	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006098	pentose-phosphate shunt	IEA	biological process
GO:0017057	6-phosphogluconolactonase activity	IDA	molecular function
GO:0006098	pentose-phosphate shunt	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa00030	Pentose phosphate pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881