• Gene id: 254827

Gene Summary

• Gene Symbol: NAALADL2   Gene   UCSC   Ensembl
• Gene name: N-acetylated alpha-linked acidic dipeptidase like 2
• Alternate names: inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2, N-acetylated alpha-linked acidic dipeptidase 2, NAALADase L2, glutamate carboxypeptidase II-type non-peptidase homologue,
• Gene location: 3q26.31 (174438533: 175810547)     Exons: 29     NC_000003.12
• OMIM: 607399

Protein Summary

• Protein general information: Q58DX5  
  • Name: Inactive N acetylated alpha linked acidic dipeptidase like protein 2 (NAALADase L2)
  • Length: 795  
  • Mass: 88682
  • Tissue specificity: Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.
• Sequence:

  MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLG
  HSETIDLNLDSIQPATSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNC
  PSDAPSSGTVDPQLYQEILKTIQAEDIKKSFRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPG
  PSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQI
  ALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGYPSVDESFRQSRSNLT
  SLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGS
  HHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYI
  SLHSPIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLE
  GPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAM
  ALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFLVKQAPPGFYRNILYHLDEKTSRFSILIEAW
  EHCKPLASNETLQEALSEVLNSINSAQVYFKAGLDVFKSVLDGKN

• Structural information:
  • Interpro: IPR007484  IPR039373  IPR036757  
  • STRING: ENSP00000404705
• Other Databases: GeneCards:  NAALADL2  Malacards:  NAALADL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0009617	response to bacterium	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq