• Gene id: 2539

Gene Summary

• Gene Symbol: G6PD   Gene   UCSC   Ensembl
• Aliases: G6PD1
• Gene name: glucose-6-phosphate dehydrogenase
• Alternate names: glucose-6-phosphate 1-dehydrogenase,
• Gene location: Xq28 (154547585: 154531389)     Exons: 14     NC_000023.11
• Gene summary(Entrez): This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynth
• OMIM: 305900

Protein Summary

• Protein general information: P11413  
  • Name: Glucose 6 phosphate 1 dehydrogenase (G6PD) (EC 1.1.1.49)
  • Length: 515  
  • Mass: 59,257
• Sequence:

  MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRL
  TVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAV
  TKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIW
  NRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
  NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHD
  VAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQM
  HFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL

• Structural information:
  • Interpro: IPR001282  IPR019796  IPR022675  IPR022674  IPR036291  
  • Prosite: PS00069
  • PDB: 1QKI 2BH9 2BHL 5UKW
  • PDBsum: 1QKI 2BH9 2BHL 5UKW
  • STRING: ENSP00000377192
• Other Databases: GeneCards:  G6PD  Malacards:  G6PD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004345	glucose-6-phosphate dehydrogenase activity	EXP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IDA	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005536	glucose binding	IDA	molecular function
GO:0005536	glucose binding	IMP	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005815	microtubule organizing center	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006098	pentose-phosphate shunt	IDA	biological process
GO:0006098	pentose-phosphate shunt	TAS	biological process
GO:0006629	lipid metabolic process	TAS	biological process
GO:0006695	cholesterol biosynthetic process	IMP	biological process
GO:0006739	NADP metabolic process	IDA	biological process
GO:0006740	NADPH regeneration	IMP	biological process
GO:0006749	glutathione metabolic process	IMP	biological process
GO:0006749	glutathione metabolic process	IMP	biological process
GO:0009051	pentose-phosphate shunt, oxidative branch	IMP	biological process
GO:0009898	cytoplasmic side of plasma membrane	IDA	cellular component
GO:0010734	negative regulation of protein glutathionylation	IMP	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0019322	pentose biosynthetic process	IDA	biological process
GO:0021762	substantia nigra development	IEP	biological process
GO:0032094	response to food	IEA	biological process
GO:0034599	cellular response to oxidative stress	IMP	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0043249	erythrocyte maturation	IMP	biological process
GO:0043523	regulation of neuron apoptotic process	IEA	biological process
GO:0045471	response to ethanol	IEA	biological process
GO:0046390	ribose phosphate biosynthetic process	IMP	biological process
GO:0050661	NADP binding	IDA	molecular function
GO:0051156	glucose 6-phosphate metabolic process	IDA	biological process
GO:0051156	glucose 6-phosphate metabolic process	IMP	biological process
GO:0055114	oxidation-reduction process	IMP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0004345	glucose-6-phosphate dehydrogenase activity	IEA	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IEA	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IEA	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	EXP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IDA	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005536	glucose binding	IEA	molecular function
GO:0005536	glucose binding	IDA	molecular function
GO:0005536	glucose binding	IMP	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005815	microtubule organizing center	IDA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006098	pentose-phosphate shunt	IEA	biological process
GO:0006098	pentose-phosphate shunt	IEA	biological process
GO:0006098	pentose-phosphate shunt	IDA	biological process
GO:0006098	pentose-phosphate shunt	TAS	biological process
GO:0006629	lipid metabolic process	TAS	biological process
GO:0006695	cholesterol biosynthetic process	IMP	biological process
GO:0006739	NADP metabolic process	IDA	biological process
GO:0006740	NADPH regeneration	IMP	biological process
GO:0006749	glutathione metabolic process	IMP	biological process
GO:0006749	glutathione metabolic process	IMP	biological process
GO:0009051	pentose-phosphate shunt, oxidative branch	IEA	biological process
GO:0009051	pentose-phosphate shunt, oxidative branch	IMP	biological process
GO:0009898	cytoplasmic side of plasma membrane	IDA	cellular component
GO:0010734	negative regulation of protein glutathionylation	IMP	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0019322	pentose biosynthetic process	IDA	biological process
GO:0021762	substantia nigra development	IEP	biological process
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0032094	response to food	IEA	biological process
GO:0034599	cellular response to oxidative stress	IMP	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0043231	intracellular membrane-bounded organelle	IEA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0043249	erythrocyte maturation	IMP	biological process
GO:0043523	regulation of neuron apoptotic process	IEA	biological process
GO:0045471	response to ethanol	IEA	biological process
GO:0046390	ribose phosphate biosynthetic process	IMP	biological process
GO:0050661	NADP binding	IEA	molecular function
GO:0050661	NADP binding	IEA	molecular function
GO:0050661	NADP binding	IDA	molecular function
GO:0051156	glucose 6-phosphate metabolic process	IEA	biological process
GO:0051156	glucose 6-phosphate metabolic process	IDA	biological process
GO:0051156	glucose 6-phosphate metabolic process	IMP	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IMP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0004345	glucose-6-phosphate dehydrogenase activity	EXP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IDA	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005536	glucose binding	IDA	molecular function
GO:0005536	glucose binding	IMP	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005815	microtubule organizing center	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006098	pentose-phosphate shunt	IDA	biological process
GO:0006098	pentose-phosphate shunt	TAS	biological process
GO:0006629	lipid metabolic process	TAS	biological process
GO:0006695	cholesterol biosynthetic process	IMP	biological process
GO:0006739	NADP metabolic process	IDA	biological process
GO:0006740	NADPH regeneration	IMP	biological process
GO:0006749	glutathione metabolic process	IMP	biological process
GO:0006749	glutathione metabolic process	IMP	biological process
GO:0009051	pentose-phosphate shunt, oxidative branch	IMP	biological process
GO:0009898	cytoplasmic side of plasma membrane	IDA	cellular component
GO:0010734	negative regulation of protein glutathionylation	IMP	biological process
GO:0016020	membrane	IDA	cellular component
GO:0019322	pentose biosynthetic process	IDA	biological process
GO:0021762	substantia nigra development	IEP	biological process
GO:0034599	cellular response to oxidative stress	IMP	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0043249	erythrocyte maturation	IMP	biological process
GO:0046390	ribose phosphate biosynthetic process	IMP	biological process
GO:0050661	NADP binding	IDA	molecular function
GO:0051156	glucose 6-phosphate metabolic process	IDA	biological process
GO:0051156	glucose 6-phosphate metabolic process	IMP	biological process
GO:0055114	oxidation-reduction process	IMP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa05230	Central carbon metabolism in cancer

Diseases

Associated diseases	References
Chronic nonspherocytic anemia.	GAD: 9298828
Cancer (lymphoma)	GAD: 17557555
Coronary heart disease	GAD: 19336475
Glucosephosphate dehydrogenase deficiency	KEGG: H01375
Alpha-thalassemia	GAD: 18458302
Anemia	KEGG: H00668
Beta-thalassemia	GAD: 18164966
Haemoglobinopathies	GAD: 3699836
Haemolytic anaemia	GAD: 9332310
Diabetes	GAD: 15914531
Glycogen storage disease	GAD: 19223928
Male factor infertility	MIK: 25297600
Hemoglobinuria	GAD: 19589177
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Male infertility	MIK: 25297600

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25297600	Male infertility, Female infertility	1376G> T, 1388G> A, 95A> G, 871G> A/1311C> T/IVS-11 93T> C, 202G> A, 835A> T, 1360C> T, 1376G> T and 392G> T/1311C> T/IVS-11 93T> C	Shenzhe n	851 infertile patients	Male infertility, Female infertility
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq