• Gene id: 253635

Gene Summary

• Gene Symbol: GPATCH11   Gene   UCSC   Ensembl
• Aliases: CCDC75, CENP-Y, CENPY
• Gene name: G-patch domain containing 11
• Alternate names: G patch domain-containing protein 11, centromere protein Y, coiled-coil domain containing 75, coiled-coil domain-containing protein 75, g patch domain-containing protein 11,
• Gene location: 2p22.2 (37084517: 37099243)     Exons: 11     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q8N954  
  • Name: G patch domain containing protein 11 (Coiled coil domain containing protein 75)
  • Length: 285  
  • Mass: 33277
• Sequence:

  MRSARSTALNRGEQRAVRYYSHMKLNMAEEEDYMSDSFINVQEDIRPGLPMLRQIREARRKEEKQQEANLKNRQK
  SLKEEEQERRDIGLKNALGCENKGFALLQKMGYKSGQALGKSGGGIVEPIPLNIKTGKSGIGHEASLKRKAEEKL
  ESYRKKIHMKNQAEEKAAEQFRMRLKNKQDEMKLEGDLRRSQRACQQLDVQKNIQVPREAWYWLRLEEETEEDEE
  EKEQDEDEYKSEDLSVLEKLQILTSYLREEHLYCIWCGTAYEDKEDLSSNCPGPTSADHD

• Structural information:
  • Protein Domains: (95..14-)
    (/note="G-patch-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00092"-)
  • Interpro: IPR025239  IPR000467  IPR039249  
  • Prosite: PS50174
  • STRING: ENSP00000386772
• Other Databases: GeneCards:  GPATCH11  Malacards:  GPATCH11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000776	kinetochore	IBA	cellular component
GO:0000776	kinetochore	IDA	cellular component
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0000776	kinetochore	IEA	cellular component
GO:0000775	chromosome, centromeric region	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000777	condensed chromosome kinetochore	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881