• Gene id: 253558

Gene Summary

• Gene Symbol: LCLAT1   Gene   UCSC   Ensembl
• Aliases: 1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
• Gene name: lysocardiolipin acyltransferase 1
• Alternate names: lysocardiolipin acyltransferase 1, 1-AGP acyltransferase 8, 1-AGPAT 8, 1-acylglycerol-3-phosphate O-acyltransferase 8, acyl-CoA:lysocardiolipin acyltransferase 1,
• Gene location: 2p23.1 (69124152: 69174415)     Exons: 10     NC_000010.11
• OMIM: 614241

Protein Summary

• Protein general information: Q6UWP7  
  • Name: Lysocardiolipin acyltransferase 1 (EC 2.3.1. ) (1 acylglycerol 3 phosphate O acyltransferase 8) (1 AGP acyltransferase 8) (1 AGPAT 8) (EC 2.3.1.51) (Acyl CoA:lysocardiolipin acyltransferase 1)
  • Length: 414  
  • Mass: 48920
  • Tissue specificity: Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO
• Sequence:

  MHSRGREIVVLLNPWSINEAVSSYCTYFIKQDSKSFGIMVSWKGIYFILTLFWGSFFGSIFMLSPFLPLMFVNPS
  WYRWINNRLVATWLTLPVALLETMFGVKVIITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLK
  ASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQ
  KYEYVLHPRTTGFTFVVDRLREGKNLDAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVHRYPIDTLPTSKEDL
  QLWCHKRWEEKEERLRSFYQGEKNFYFTGQSVIPPCKSELRVLVVKLLSILYWTLFSPAMCLLIYLYSLVKWYFI
  ITIVIFVLQERIFGGLEIIELACYRLLHKQPHLNSKKNE

• Structural information:
  • Interpro: IPR032098  IPR002123  
  • STRING: ENSP00000310551
• Other Databases: GeneCards:  LCLAT1  Malacards:  LCLAT1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005783	endoplasmic reticulum	IBA	cellular component
GO:0012505	endomembrane system	IBA	cellular component
GO:0016746	transferase activity, transferring acyl groups	IBA	molecular function
GO:0036149	phosphatidylinositol acyl-chain remodeling	IBA	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	molecular function
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	molecular function
GO:0035965	cardiolipin acyl-chain remodeling	TAS	biological process
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0008654	phospholipid biosynthetic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	IEA	molecular function
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0006654	phosphatidic acid biosynthetic process	TAS	biological process
GO:0008374	O-acyltransferase activity	TAS	molecular function
GO:0008374	O-acyltransferase activity	TAS	molecular function
GO:0035965	cardiolipin acyl-chain remodeling	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0016024	CDP-diacylglycerol biosynthetic process	IEA	biological process
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00564	Glycerophospholipid metabolism
hsa00561	Glycerolipid metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq