• Gene id: 252983

Gene Summary

• Gene Symbol: STXBP4   Gene   UCSC   Ensembl
• Aliases: Synip
• Gene name: syntaxin binding protein 4
• Alternate names: syntaxin-binding protein 4, STX4-interacting protein, syntaxin 4 interacting protein,
• Gene location: 17q22 (54968727: 55173631)     Exons: 21     NC_000017.11
• OMIM: 610415

Protein Summary

• Protein general information: Q6ZWJ1  
  • Name: Syntaxin binding protein 4 (Syntaxin 4 interacting protein) (STX4 interacting protein) (Synip)
  • Length: 553  
  • Mass: 61662
• Sequence:

  MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNK
  ESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPK
  TSSTPKTNNDILSSCEIKTGYNKTVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALN
  YLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL
  KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIR
  LLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSN
  LSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWI
  HPVMSVLNLSRSEENEEDCSRELPNQKS

• Structural information:
  • Protein Domains: (19..10-)
    (/note="PDZ-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00143-)
    (496..52-)
    (/note="WW-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00224"-)
  • Interpro: IPR001478  IPR036034  IPR001202  IPR036020  
  • Prosite: PS50106 PS01159 PS50020
  • CDD: cd00201
  • PDB: 2YSG
  • PDBsum: 2YSG
  • STRING: ENSP00000365530
• Other Databases: GeneCards:  STXBP4  Malacards:  STXBP4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IEA	cellular component
GO:0006605	protein targeting	IEA	biological process
GO:0008286	insulin receptor signaling pathway	IEA	biological process
GO:0010827	regulation of glucose transmembrane transport	IEA	biological process
GO:0071346	cellular response to interferon-gamma	IEA	biological process
GO:0045335	phagocytic vesicle	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006974	cellular response to DNA damage stimulus	IDA	biological process
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IDA	biological process
GO:0010838	positive regulation of keratinocyte proliferation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0019905	syntaxin binding	IPI	molecular function
GO:1902808	positive regulation of cell cycle G1/S phase transition	IMP	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0050821	protein stabilization	IMP	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)