• Gene id: 2519

Gene Summary

• Gene Symbol: FUCA2   Gene   UCSC   Ensembl
• Aliases: dJ20N2.5
• Gene name: alpha-L-fucosidase 2
• Alternate names: plasma alpha-L-fucosidase, I+/--L-fucosidase 2, a-L-fucosidase 2, alpha-L-fucoside fucohydrolase 2, fucosidase, alpha-L- 2, plasma, plasma fucosidase,
• Gene location: 6q24.2 (143511719: 143494811)     Exons: 7     NC_000006.12
• Gene summary(Entrez): This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reduci
• OMIM: 136820

Protein Summary

• Protein general information: Q9BTY2  
  • Name: Plasma alpha L fucosidase (EC 3.2.1.51) (Alpha L fucoside fucohydrolase 2) (Alpha L fucosidase 2)
  • Length: 467  
  • Mass: 54067
• Sequence:

  MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIHWGVFSVPSFGSEWFW
  WYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVLTSKHHEGFTLWGSEYSWNW
  NAIDEGPKRDIVKELEVAIRNRTDLRFGLYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVL
  WSDGDGGAPDQYWNSTGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKL
  SWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQMGSWLKVNGEAIYETHTWRS
  QNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGATEVKLLGHGQPLNWISLEQNGIMVELPQLTI
  HQMPCKWGWALALTNVI

• Structural information:
  • Interpro: IPR016286  IPR031919  IPR000933  IPR018526  IPR013780   IPR017853  
  • Prosite: PS00385
  • STRING: ENSP00000002165
• Other Databases: GeneCards:  FUCA2  Malacards:  FUCA2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005764	lysosome	IBA	cellular component
GO:0016139	glycoside catabolic process	IBA	biological process
GO:0004560	alpha-L-fucosidase activity	IBA	molecular function
GO:0006004	fucose metabolic process	IBA	biological process
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0004560	alpha-L-fucosidase activity	IEA	molecular function
GO:0006004	fucose metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	molecular function
GO:0004560	alpha-L-fucosidase activity	IEA	molecular function
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0044267	cellular protein metabolic process	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0035578	azurophil granule lumen	TAS	cellular component
GO:0043687	post-translational protein modification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016139	glycoside catabolic process	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0006004	fucose metabolic process	IDA	biological process
GO:0004560	alpha-L-fucosidase activity	IDA	molecular function
GO:2000535	regulation of entry of bacterium into host cell	IMP	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0009617	response to bacterium	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04142	Lysosome
hsa00511	Other glycan degradation

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881