• Gene id: 247

Gene Summary

• Gene Symbol: ALOX15B   Gene   UCSC   Ensembl
• Aliases: 15-LOX-2
• Gene name: arachidonate 15-lipoxygenase type B
• Alternate names: arachidonate 15-lipoxygenase B, 15-LOX-B, 15S-lipoxygenase, arachidonate 15-lipoxygenase 2, arachidonate 15-lipoxygenase type II, arachidonate 15-lipoxygenase, second type, arachidonate omega(6) lipoxygenase, linoleate 13-lipoxygenase 15-LOb,
• Gene location: 17p13.1 (8039039: 8049133)     Exons: 14     NC_000017.11
• Gene summary(Entrez): This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic a
• OMIM: 600744

Protein Summary

• Protein general information: O15296  
  • Name: Arachidonate 15 lipoxygenase B (15 LOX B) (EC 1.13.11.33) (15 lipoxygenase 2) (15 LOX 2) (Arachidonate 15 lipoxygenase type II) (Linoleate 13 lipoxygenase 15 LOb) (EC 1.13.11. )
  • Length: 676  
  • Mass: 75857
  • Tissue specificity: Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. {ECO
• Sequence:

  MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPV
  LPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQ
  WKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAA
  EHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
  NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLL
  HSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLN
  YSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQES
  SGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
  CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVS
  I

• Structural information:
  • Protein Domains: (2..12-)
    (/note="PLAT-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00152-)
    (125..67-)
    (/note="Lipoxygenase-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00726"-)
  • Interpro: IPR000907  IPR013819  IPR036226  IPR020834  IPR020833   IPR001885  IPR001024  IPR036392  IPR042062  
  • Prosite: PS00711 PS00081 PS51393 PS50095
  • CDD: cd01753
  • PDB: 4NRE
  • PDBsum: 4NRE
  • STRING: ENSP00000369530
• Other Databases: GeneCards:  ALOX15B  Malacards:  ALOX15B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050473	arachidonate 15-lipoxygenase activity	IBA	molecular function
GO:0043651	linoleic acid metabolic process	IBA	biological process
GO:0019372	lipoxygenase pathway	IBA	biological process
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA	molecular function
GO:0051122	hepoxilin biosynthetic process	IBA	biological process
GO:0034440	lipid oxidation	IBA	biological process
GO:0019369	arachidonic acid metabolic process	IBA	biological process
GO:0006644	phospholipid metabolic process	IDA	biological process
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:2001303	lipoxin A4 biosynthetic process	IDA	biological process
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0005912	adherens junction	IDA	cellular component
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0019898	extrinsic component of membrane	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005506	iron ion binding	IDA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0006629	lipid metabolic process	IDA	biological process
GO:0006629	lipid metabolic process	IDA	biological process
GO:0019369	arachidonic acid metabolic process	IDA	biological process
GO:0005925	focal adhesion	IDA	cellular component
GO:0071926	endocannabinoid signaling pathway	IDA	biological process
GO:1901696	cannabinoid biosynthetic process	IDA	biological process
GO:0019369	arachidonic acid metabolic process	IDA	biological process
GO:0019369	arachidonic acid metabolic process	IDA	biological process
GO:0019369	arachidonic acid metabolic process	IDA	biological process
GO:0019369	arachidonic acid metabolic process	IDA	biological process
GO:0016165	linoleate 13S-lipoxygenase activity	IDA	molecular function
GO:0016020	membrane	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005856	cytoskeleton	IDA	cellular component
GO:0090197	positive regulation of chemokine secretion	IMP	biological process
GO:0010744	positive regulation of macrophage derived foam cell differentiation	IMP	biological process
GO:0008285	negative regulation of cell population proliferation	IMP	biological process
GO:0051122	hepoxilin biosynthetic process	ISS	biological process
GO:0005506	iron ion binding	IEA	molecular function
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0008289	lipid binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0030054	cell junction	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0051213	dioxygenase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0050473	arachidonate 15-lipoxygenase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0019372	lipoxygenase pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0045618	positive regulation of keratinocyte differentiation	IEA	biological process
GO:0043651	linoleic acid metabolic process	IEA	biological process
GO:0036403	arachidonate 8(S)-lipoxygenase activity	IEA	molecular function
GO:0019372	lipoxygenase pathway	IEA	biological process
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	IEA	biological process
GO:0019369	arachidonic acid metabolic process	IEA	biological process
GO:0005912	adherens junction	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005925	focal adhesion	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0050473	arachidonate 15-lipoxygenase activity	IDA	molecular function
GO:0008285	negative regulation of cell population proliferation	IDA	biological process
GO:0045786	negative regulation of cell cycle	IDA	biological process
GO:0019369	arachidonic acid metabolic process	IDA	biological process
GO:0045926	negative regulation of growth	IDA	biological process
GO:0006915	apoptotic process	TAS	biological process
GO:0006629	lipid metabolic process	TAS	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0030850	prostate gland development	NAS	biological process
GO:0030856	regulation of epithelial cell differentiation	NAS	biological process
GO:0030336	negative regulation of cell migration	TAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04726	Serotonergic synapse
hsa00590	Arachidonic acid metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray