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Gene id 246
Gene Summary     SNPs    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol ALOX15   Gene   UCSC   Ensembl
Aliases 12-LOX, 15-LOX, 15-LOX-1, LOG15
Gene name arachidonate 15-lipoxygenase
Alternate names arachidonate 15-lipoxygenase, 12/15-lipoxygenase, 15-LOX type 1, 15-lipooxygenase-1, 15-lipoxygenase type 1, arachidonate 12-lipoxygenase, leukocyte-type, arachidonate omega-6 lipoxygenase,
Gene location 17p13.2 (4641677: 4630918)     Exons: 14     NC_000017.11
Gene summary(Entrez) This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The e
OMIM 152392

SNPs


rs17855750

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000016.10   g.28503907A>C
NC_000016.10   g.28503907A>T
NC_000016.9   g.28515228A>C
NC_000016.9   g.28515228A>T
NM_145659.3   c.175T>G
NM_145659.3   c.175T>A
XM_011545780.2   c.181T>G
XM_011545780.2   c.181T>A
NP_663634.2   p.Ser59Ala
NP_663634.2   p.Ser59Thr
XP_01154  

rs4997052

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.31356367T>A
NC_000006.12   g.31356367T>G
NC_000006.11   g.31324144T>A
NC_000006.11   g.31324144T>G
NG_023187.1   g.5846A>T
NG_023187.1   g.5846A>C
NM_005514.8   c.419A>T
NM_005514.8   c.419A>C
NM_005514.7   c.419A>T
NM_005514.7   c.419A>C
NM_005514.6   c.

rs153109

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000016.10   g.28507775T>C
NC_000016.9   g.28519096T>C|SEQ=[T/C]|GENE=IL27

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa01100Metabolic pathways
hsa04216Ferroptosis
hsa04217Necroptosis
hsa04726Serotonergic synapse
Associated diseases References
Cancer GAD: 19692168
Atherosclerosis GAD: 18392641
Carotid artery diseases GAD: 18392641
Brain ischemia GAD: 18392641
Myocardial Infarction GAD: 18392641
Myocardial Infarction GAD: 19131063
Asthma GAD: 18774388
Stroke GAD: 18392641
Alzheimer's disease GAD: 19141999
Female infertility GAD: 18692814
Endometriosis INFBASE: 18692814
Chronic obstructive pulmonary disease (COPD) GAD: 19625176
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Cryptorchidism MIK: 28606200
Male subfertility MIK: 20449608
Altered sperm maturation MIK: 20449608
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
20449608 Male subfe
rtility, d
isplaying
normal spe
rmatogenes
is but alt
ered sperm
maturatio
n


Male infertility
Show abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract
28606200 Cryptorchi
dism

Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
Male infertility MeDIP-Seq
Show abstract